Products Diltiazem is commercially available in tablet and capsule form (Dilzem, generic). It has been approved in many countries since 1982. Structure and properties Diltiazem (C22H26N2O4S, Mr = 414.52 g/mol) is a benzothiazepine derivative. It is present in drugs as diltiazem hydrochloride, a white crystalline powder with a bitter taste that is readily soluble in … Diltiazem
Products Dihydropyridines are commercially available in many countries in the form of film-coated tablets, sustained-release tablets, capsules, and injectables. Nifedipine from Bayer (Adalat) was the first active ingredient from this group to enter the market in the mid-1970s. Today, amlodipine (Norvasc, generics) is most commonly prescribed. Structure and properties The name 1,4-dihydropyridines is derived from … Dihydropyridine
Products Diltiazem ointments are not registered as finished drug products in many countries. However, they can be prepared as an extemporaneous prescription in a pharmacy. Typically, two-percent dosage forms are used (gel, cream, or ointment). There are various manufacturing instructions. For example, white petroleum jelly, Excipial oily ointment, DAC base cream, or a gel base … Diltiazem Ointment
Products Felodipine is commercially available in the form of sustained-release tablets. In addition to the original Plendil, generic versions are also available. It has been approved in many countries since 1988. Structure and properties Felodipine (C18H19Cl2NO4, Mr = 384.3 g/mol) is a dihydropyridine. It exists as a white to pale yellow crystalline powder that is … Felodipine
Products Nifedipine is commercially available in the form of sustained-release tablets (generics). It was first approved in the mid-1970s. Sales of the original Adalat were discontinued in many countries in 2019. Structure and properties Nifedipine (C17H18N2O6, Mr = 346.3 g/mol) is a dihydropyridine. It exists as a yellow crystalline powder that is practically insoluble in … Nifedipine: Drug Effects, Side Effects, Dosage and Uses
Products Isradipine is commercially available in capsule form (Lomir SRO). It has been approved in many countries since 1991. Structure and properties Isradipine (C19H21N3O5, Mr = 371.4 g/mol) is a racemate. It exists as a yellow crystalline powder that is practically insoluble in water. Effects Isradipine (ATC C08CA03) has antihypertensive properties. Its effects are due … Isradipine
Products Lercanidipine is commercially available in the form of film-coated tablets (Zanidip, Zanipress + enalapril). It has been approved in many countries since 2004. Generic versions were registered in 2014. Structure and properties Lercanidipine (C36H41N3O6, Mr = 611.7 g/mol) is a dihydropyridine. It is present in drugs as lercanidipine hydrochloride. The -enantiomer is primarily active. … Lercanidipine
Products Nimodipine is commercially available as an infusion solution and tablets (Nimotop). It has been approved in many countries since 1987. Structure and properties Nimodipine (C21H26N2O7, Mr = 418.4 g/mol) is a racemate. It exists as a pale yellow to yellow crystalline powder that is practically insoluble in water. Effects Nimodipine (ATC C08CA06) has cerebral … Nimodipine
Products Nitrendipine is commercially available in tablet form (Baypress / – mite). It was approved in many countries since 1985. In 2017, its distribution was discontinued. Structure and properties Nitrendipine (C18H20N2O6, Mr = 360.4 g/mol) is a dihydropyridine and a racemate. It exists as a yellow crystalline powder that is practically insoluble in water. The … Nitrendipine
Products Verapamil is commercially available in the form of film-coated tablets and sustained-release tablets (Isoptin, generic). It has been approved in many countries since 1964. Verapamil is also combined fixed with trandolapril (Tarka). Structure and properties Verapamil (C27H38N2O4, Mr = 454.60 g/mol) is a racemate consisting of the – and -enantiomer. It is an analog … Verapamil: Drug Effects, Side Effects, Dosage and Uses
Products Cinnarizine is commercially available in the form of capsules, tablets, and drops (Stugeron, generic). It has been approved in many countries since 1968. Since 2012, a fixed combination with dimenhydrinate has been on the market in many countries (Arlevert) see under Cinnarizine and Dimenhydrinate. Structure and properties Cinnarizine (C26H28N2, Mr = 368.51 g/mol) exists … Cinnarizine Effects and Side Effects
Products Amlodipine is commercially available in tablet form (Norvasc, generic). It has been approved in many countries since 1990. Amlodipine is also combined fixed with the following agents: Aliskiren, atorvastatin, perindopril, telmisartan, valsartan, olmesartan, hydrochlorothiazide, and indapamide. Structure and properties Amlodipine (C20H25ClN2O5, Mr = 408.9 g/mol) has a chiral center and is a racemate. It … Amlodipine (Norvasc)
