Cotrimoxazole: Effects, Applications, Side Effects

How cotrimoxazole works Cotrimoxazole is a combination preparation of the antibiotics sulfamethoxazole and trimethoprim. Both substances inhibit the formation of folic acid in certain bacteria and fungi. This is needed for the synthesis of some building blocks of genetic material (thymidine and purines). Cotrimoxazole interrupts folic acid synthesis in two different ways: Trimethoprim inhibits the … Cotrimoxazole: Effects, Applications, Side Effects