Products Melphalan is commercially available in the form of film-coated tablets and as an injection/infusion preparation (Alkeran). It has been approved in many countries since 1964. Structure and properties Melphalan (C13H18Cl2N2O2, Mr = 305.2 g/mol) is a phenylalanine derivative of nitrogen-lost. It is practically insoluble in water. It exists as a pure L-enantiomer. The racemate … Melphalan
Products Carmustine is commercially available in many countries as a powder and solvent for the preparation of an infusion solution (BiCNU). An implant is also available in some countries (Gliadel). Structure and properties Carmustine (C5H9Cl2N3O2, Mr = 214.0 g/mol) belongs to the nitrosoureas. It exists as a yellowish, granular powder that is very sparingly soluble … Carmustine
Products Temozolomide is commercially available as capsules and as a powder for the preparation of an infusion solution (Temodal, generics). It has been approved in many countries since 1999. Structure and properties Temozolomide (C6H6N6O2, Mr = 194.2 g/mol) is an imidazotetrazine derivative. It is a prodrug that is biotransformed by hydrolysis to the active metabolite … Temozolomide
Products Streptozocin is no longer commercially available in many countries. Zanosar is no longer available. Structure and properties Streptozocin (C8H15N3O7, Mr = 265.2 g/mol) is a -nitrosourea. Effects Streptozocin (ATC L01AD04) is cytotoxic. Indications For the treatment of metastatic pancreatic islet cell carcinoma.
Products Treosulfan was approved in the EU in 2019 and in many countries in 2020 as a powder for the preparation of an infusion solution (Trecondi). Structure and properties Treosulfan (C6H14O8S2, Mr = 278.3 g/mol) Effects Treosulfan (ATC L01AB02) has cytotoxic and antineoplastic properties. It is a prodrug of a bifunctional alkylating agent active against … Treosulfan
Products Bendamustine is commercially available as a lyophilizate for the preparation of an infusion solution (ribomustine). It actually has good oral bioavailability when taken fasting, but is only administered parenterally. Generic drugs are registered. Bendamustine was developed in 1963 by Ozegowski et al. in Jena in what was then East Germany and was marketed only … Bendamustine
Products Chlorambucil is commercially available in the form of film-coated tablets (Leukeran). It has been approved in many countries since 1957. Structure and properties Chlorambucil (C14H19Cl2NO2, Mr = 304.2 g/mol) is an aromatic nitrogen-lost derivative. It exists as a white crystalline powder that is practically insoluble in water. The effects are due to the active … Chlorambucil
