Products Trametinib was approved in the form of film-coated tablets in the United States in 2013, in the EU in 2014, and in many countries in 2016 (Mekinist). Structure and properties Trametinib (C26H23FIN5O4, Mr = 615.4 g/mol) is a pyridine and a pyrimidine derivative. It is present in the drug product as trametinib dimethyl sulfoxide, … Trametinib
Products Cobimetinib is commercially available in the form of film-coated tablets (Cotellic). It was approved in many countries in 2015. Structure and properties Cobimetinib (C21H21F3IN3O2, Mr = 531.3 g/mol) is present in the drug as cobimetinib hemifumarate, a white crystalline substance whose solubility is pH-dependent. Effects Cobimetinib (ATC L01XE38) has antitumor and antiproliferative properties. The … Cobimetinib
Products Binimetinib was approved in the EU and US in 2018 and in many countries in 2019 in film-coated tablet form (Mektovi). Structure and properties Binimetinib (C17H15BrF2N4O3, Mr = 441.2 g/mol) exists as a light yellow powder that is practically insoluble in water. Effects Binimetinib (ATC L01XE41) has antitumor and antiproliferative properties. The effects are … Binimetinib