Products Nalmefene is commercially available in the form of film-coated tablets (Selincro). It was registered in many countries in 2014. Structure and properties Nalmefene (C21H25NO3, Mr = 339.4 g/mol) is structurally closely related to naltrexone, from which it is derived. In the drug product, it is present as nalmefene hydrochloride and dihydrate, a white crystalline … Nalmefene
Products Naloxegol is commercially available in the form of film-coated tablets (Moventig, USA: Movantik). It was approved in many countries in 2015. Structure and properties Naloxegol (C34H53NO11, Mr = 651.8 g/mol) is a pegylated derivative of naloxone. It exists as naloxegoloxalate, a white powder that is highly soluble in water. Effects Naloxegol (ATC A06AH03) is … Naloxegol
Products Methylnaltrexone is commercially available as a solution for injection (Relistor). It has been approved in many countries since 2009. Structure and properties Methylnaltrexone (C21H26NO4, Mr = 356.4 g/mol) is an -methylated naltrexone. It is present in drugs as methylnaltrexone bromide. Effects Methylnaltrexone (ATC A06AH01) counteracts constipation caused by opioids. The effects are due to … Methylnaltrexone
Products Naloxone is commercially available as a solution for injection (Naloxone OrPha, Naloxone Actavis) and has been approved in many countries since 2004. Information on combination with oxycodone is presented under the article Oxycodone and Naloxone (Targin, Peroral). As a fixed combination with buprenorphine, naloxone is used to treat opioid dependence (Suboxone, sublingual). In 2014, … Naloxone
Products Naloxone nasal spray was approved in the United States in 2015 (Narcan), in the EU in 2017, and in many countries in 2018 (Nyxoid). Each nasal spray contains only one dose and can be used only once. Structure and properties Naloxone (C19H21NO4, Mr = 327.37 g/mol) is a semisynthetic derivative of morphine. It is … Naloxone Nasal Spray
Products Naltrexone is commercially available in the form of film-coated tablets (naltrexin). It has been approved in many countries since 2003. Structure and properties Naltrexone (C20H23NO4, Mr = 341.40 g/mol) is a synthetically produced opioid related to oxymorphone. It is present in drugs as naltrexone hydrochloride, a white, hygroscopic powder that is readily soluble in … Naltrexone
