Proteasome Inhibitors

Carfilzomib

Products Carfilzomib was approved in many countries in 2015 as a powder for the preparation of an infusion solution (Kyprolis). Structure and properties Carfilzomib (C40H57N5O7, Mr = 719.9 g/mol) exists as a crystalline substance that is practically insoluble in water. It is a peptide derivative, a tetrapeptide epoxyketone. Epoxyketones are derivatives of epoxomicin, a natural … Carfilzomib

Ixazomib

Products Ixazomib was approved in capsule form in the United States in 2015, in the EU in 2016, and in many countries in 2017 (Ninlaro). Structure and properties Ixazomib is present in drugs in the form of the prodrug ixazomib citrate (C14H19BCl2N2O4, Mr = 361.0 g/mol) is present. In the body, it is hydrolyzed to … Ixazomib