Topical Calcineurin Inhibitors

Pimecrolimus

Products Pimecrolimus is commercially available as a cream (Elidel). It has been approved in many countries since 2003. Structure and properties Pimecrolimus (C43H68ClNO11, Mr = 810.5 g/mol) is a lipophilic macrolactam derivative of ascomycin, an ethyl analog of tacrolimus. It exists as a white crystalline powder that is insoluble in water. Effects Pimecrolimus (ATC D11AX15) … Pimecrolimus

Topical Tacrolimus

Products Tacrolimus is commercially available for external use as an ointment in two concentrations (Protopic). It has been approved in many countries since 2001. Structure and properties Tacrolimus (C44H69NO12 – H2O, Mr = 822.0 g/mol) is a complex macrolide formed by the fungus-like bacterium. It is present in drugs as tacrolimus monohydrate, white crystals, or … Topical Tacrolimus