Glomerulonephritis

Minimal-change Glomerulonephritis: Therapy

General measures Nicotine restriction (refraining from tobacco use). Review of permanent medication due topossible effect on the existing disease. Vaccinations The following vaccinations are advised, as infection can often lead to worsening of the present disease: Flu vaccination Hepatitis B vaccination Pneumococcal vaccination Regular checkups Regular medical checkups Nutritional medicine Nutritional counseling based on nutritional … Minimal-change Glomerulonephritis: Therapy

Minimal-change Glomerulonephritis: Drug Therapy

Therapeutic target Avert deterioration of renal function. Therapy recommendations Therapy for minimal-change glomerulonephritis is still empiric. Use of glucocorticoids (first-line therapy); at least 4 weeks after achieving remission (temporal or permanent remission of disease symptoms), but for a maximum of 16 weeks. Therapy in steroid-resistant cases or frequent relapses – after confirmation by re-biopsy (re-taking … Minimal-change Glomerulonephritis: Drug Therapy

Minimal-change Glomerulonephritis: Diagnostic Tests

Obligatory medical device diagnostics. Renal ultrasonography (ultrasound examination of the kidneys). Renal biopsy (tissue sampling from the kidney) – for definitive diagnosis, treatment planning, prognosis assessment [in electron microscopy global fusion of podocytic foot processes with largely normal light microscopic findings].

Minimal-change Glomerulonephritis: Micronutrient Therapy

An at-risk group indicates the possibility that the disease may be associated with the risk of vital substance (micronutrient) deficiency. The complaint nephrotic syndrome indicates vital nutrient (micronutrient) deficiency for: Calcium Iron Copper Zinc A risk group indicates the possibility that the disease may be associated with the risk of vital substance deficiency (micronutrients). The … Minimal-change Glomerulonephritis: Micronutrient Therapy

Minimal-change Glomerulonephritis: Prevention

To prevent minimal-change glomerulonephritis, attention must be paid to reducing individual risk factors. Medications Interferon α-drugs with antiviral (directed against viruses), growth inhibitory, and immunoregulatory properties. Lithium Non-steroidal anti-inflammatory drugs (NSAIDs) – painkillers such as ibuprofen. Penicillamine (chelating agents) Mercury Rifampicin – antibiotic (drug against bacterial infections). Other risk factors After vaccinations

Minimal-change Glomerulonephritis: Symptoms, Complaints, Signs

The following symptoms and complaints may indicate minimal-change glomerulonephritis: Leading symptoms Generalized edema – water retention occurring throughout the body. Proteinuria – increased excretion of protein in the urine. Hypoproteinemia – too little protein in the blood. Derailment of fat metabolism Associated symptoms Hypertension (high blood pressure)

Minimal-change Glomerulonephritis: Causes

Pathogenesis (disease development) The exact causes leading to minimal change glomerulonephritis (MCGN) are still unknown. An autoimmunologic component is thought to be involved. There is thought to be impaired T-cell activity (T-lymphocytes, or T-cells for short, form a group of white blood cells used for immune defense) and, as a consequence, dysfunction of podocytes (cells … Minimal-change Glomerulonephritis: Causes

Minimal-change Glomerulonephritis: Complications

The following are the most important diseases or complications that may be contributed to by minimal-change glomerulonephritis: Cardiovascular system (I00-I99). Pulmonary embolism – occlusion of pulmonary vessels due to a detached thrombus. Thrombosis (vein occlusion) Genitourinary system (kidneys, urinary tract – sex organs) (N00-N99) Nephrotic syndrome – collective term for symptoms that occur in various … Minimal-change Glomerulonephritis: Complications

Minimal-change Glomerulonephritis: Examination

A comprehensive clinical examination is the basis for selecting further diagnostic steps: General physical examination – including blood pressure, pulse, body weight, height; further: Inspection (viewing). Skin and mucous membranes [leading symptoms: generalized edema (water retention occurring throughout the body); morning swelling of eyelids, face, lower legs] Auscultation (listening) of the heart [due topossible sequelae: … Minimal-change Glomerulonephritis: Examination

Minimal-change Glomerulonephritis: Test and Diagnosis

1st order laboratory parameters – obligatory laboratory tests. Small blood count Urine status (rapid test for: pH, leukocytes, nitrite, protein, glucose, ketone, urobilinogen, bilirubin, blood), sediment, urine culture if necessary (pathogen detection and resistogram, i.e. testing suitable antibiotics for sensitivity/resistance). Erythrocyte morphology (shape of the erythrocytes / red blood cells) by phase contrast microscopy [dysmorphic … Minimal-change Glomerulonephritis: Test and Diagnosis

Minimal-change Glomerulonephritis: Medical History

Medical history (history of illness) represents an important component in the diagnosis of minimal-change glomerulonephritis. Family history Is there a history of frequent kidney disease in your family? Social history Current medical history/systemic history (somatic and psychological complaints). Have you noticed water retention on your body? Have you noticed any changes in your urine? Vegetative … Minimal-change Glomerulonephritis: Medical History

Minimal-change Glomerulonephritis: Or something else? Differential Diagnosis

Blood, blood-forming organs-immune system (D50-D90). Schönlein-Henoch purpura (age <20 years). Genitourinary system (kidneys, urinary tract – reproductive organs) (N00-N99). Other forms of glomerulonephritis Benign familial hematuria (synonym: thin basement membrane nephropathy) – isolated, familial persistent glomerular hematuria (blood in the urine) and minimal proteinuria (excretion of protein in the urine) with normal renal function.