Membranoese

Membranous Glomerulonephritis: Medical History

Medical history (history of illness) represents an important component in the diagnosis of membranous glomerulonephritis. Family history Is there a history of frequent kidney disease in your family? Social history What is your profession? Are you exposed to harmful working substances in your profession? Current medical history/systemic medical history (somatic and psychological complaints). Have you … Membranous Glomerulonephritis: Medical History

Membranous Glomerulonephritis: Or something else? Differential Diagnosis

Blood, hematopoietic organs-immune system (D50-D90). Schönlein-Henoch purpura (age <20 years). Genitourinary system (kidneys, urinary tract – reproductive organs) (N00-N99). Other forms of glomerulonephritis Benign familial hematuria (synonym: thin basement membrane nephropathy) – isolated, familial persistent glomerular hematuria (blood in the urine) and minimal proteinuria (excretion of protein in the urine) with normal renal function.

Membranous Glomerulonephritis: Complications

The following are the major diseases or complications that may be contributed to by membranous glomerulonephritis: Cardiovascular system (I00-I99). Thrombosis (venous occlusion) Pulmonary embolism – occlusion of pulmonary vessels due to a detached thrombus. Genitourinary system (kidneys, urinary tract – reproductive organs) (N00-N99). Renal insufficiency (kidney weakness)/renal failure with dialysis requirement or need for kidney … Membranous Glomerulonephritis: Complications

Membranous Glomerulonephritis: Examination

A comprehensive clinical examination is the basis for selecting further diagnostic steps: General physical examination – including blood pressure, pulse, body weight, height; further: Inspection (viewing). Skin and mucous membranes [leading symptoms: generalized edema (water retention occurring throughout the body); morning swelling of eyelids, face, lower legs] Auscultation (listening) of the heart [due topossible sequelae: … Membranous Glomerulonephritis: Examination

Membranous Glomerulonephritis: Test and Diagnosis

1st order laboratory parameters – obligatory laboratory tests. Small blood count Urine status (rapid test for: pH, leukocytes, nitrite, protein, glucose, ketone, urobilinogen, bilirubin, blood), sediment, urine culture if necessary (pathogen detection and resistogram, i.e. testing suitable antibiotics for sensitivity/resistance). Assessment of erythrocyte morphology. [dysmorphic erythrocytes (malformed red blood cells): especially acanthocytes (= erythrocytes with … Membranous Glomerulonephritis: Test and Diagnosis

Membranous Glomerulonephritis: Drug Therapy

Therapeutic target Avert deterioration of renal function Note: If there is a normal glomerular filtration rate (GFR; total volume of primary urine produced by all glomeruli (renal corpuscles) of both kidneys combined per time) and subnephrotic proteinuria (protein < 3.5 g/day), spontaneous progression can be awaited. Therapy recommendations If proteinuria (increased excretion of protein in … Membranous Glomerulonephritis: Drug Therapy

Membranous Glomerulonephritis: Diagnostic Tests

Obligatory medical device diagnostics. Renal sonography (ultrasonography of the kidneys). Renal biopsy (tissue sampling from the kidney) – for definitive diagnosis, treatment planning, prognosis assessment [pathognomonic evidence of IgA deposits in the glomerular mesangium (characteristic of the disease)].

Membranous Glomerulonephritis: Micronutrient Therapy

A risk group indicates the possibility that the disease may be associated with the risk of vital substance (micronutrient) deficiency. The complaint nephrotic syndrome indicates vital nutrient (micronutrient) deficiency for: Calcium Iron Copper Zinc A risk group indicates the possibility that the disease may be associated with the risk of vital substance deficiency (micronutrients). The … Membranous Glomerulonephritis: Micronutrient Therapy

Membranous Glomerulonephritis: Prevention

To prevent membranous glomerulonephritis, attention must be paid to reducing individual risk factors. Medications Captopril – antihypertensive (medication for high blood pressure). Chloromethiazole – drug given during withdrawal. Gold – was used as a drug for rheumatism Non-steroidal anti-inflammatory drugs (NSAIDs) – painkillers such as ibuprofen. Penicillamine (chelating agents) Probenecid (gout agent) Trimethadione – antiepileptic … Membranous Glomerulonephritis: Prevention

Membranous Glomerulonephritis: Symptoms, Complaints, Signs

The following symptoms and complaints may indicate membranous glomerulonephritis: Leading symptoms Generalized edema (water retention all over the body). Proteinuria (increased excretion of protein in the urine). Accompanying symptom Hypertension (high blood pressure)

Membranous Glomerulonephritis: Causes

Pathogenesis (disease development) In most cases, membranous glomerulonephritis occurs as primary glomerulonephritis, at least in Germany. In this case, complexes of antigens and antibodies are formed in the glomeruli (renal corpuscles), so autoantibodies may be causative. In up to 80% of cases, the cause is unknown (primary membranous glomerulonephritis). In Asia, membranous glomerulonephritis is not … Membranous Glomerulonephritis: Causes

Membranous Glomerulonephritis: Therapy

General measures Nicotine restriction (refraining from tobacco use). Review of permanent medication due topossible effect on the existing disease. Avoidance of environmental stress: Mercury Vaccinations The following vaccinations are advised, as infection can often lead to worsening of the present disease: Flu vaccination Hepatitis B vaccination Pneumococcal vaccination Regular checkups Regular medical checkups Nutritional medicine … Membranous Glomerulonephritis: Therapy