Optional medical device diagnostics – depending on the results of the history, physical examination, laboratory diagnostics, and mandatory medical device diagnostics – for symptomatic bleeding. Sonography (ultrasound) of the affected body region X-ray of the affected body region Computed tomography (CT) of the affected body region.
The following symptoms and complaints may indicate an increased tendency to bleed: Leading symptoms Purpura – reddish-dark red lesions caused by small-spotted capillary hemorrhage in the skin (gr. derma; also cutis from Latin cutis), subcutis, or mucous membranes (skin and mucous membrane hemorrhage); the individual hemorrhage may present as follows: Petechie (lat. petechia, pl. petechiae) … Bleeding Tendency: Symptoms, Complaints, Signs
Medical history (history of illness) represents an important component in the diagnosis of increased bleeding tendency. Family history What is the general health of your family members? Are there any diseases in your family that are common? Are there any hereditary diseases in your family? Social history What is your profession? Current medical history/systemic history … Bleeding Tendency: Medical History
Blood, hematopoietic organs-immune system (D50-D90). Bleeding tendency (uremic) – bleeding time prolonged by uremia (occurrence of urinary substances in the blood above normal values). Coagulation defects: Disseminated Intravascular Coagulation (DIC) – acquired life-threatening condition in which clotting factors are depleted in the vasculature due to excessive blood clotting, resulting in a bleeding tendency. Liver failure … Bleeding Tendency: Or something else? Differential Diagnosis
A comprehensive clinical examination is the basis for selecting further diagnostic steps: General physical examination – including blood pressure, pulse, body weight, height; furthermore: Inspection (viewing) of skin, mucous membranes, and sclera (white part of eye) [skin and mucous membrane bleeding; hematoma/bruising]. Palpation (palpation) of the abdomen, etc. [hepatomegaly (enlargement of the liver); splenomegaly (enlargement … Bleeding Tendency: Examination
1st order laboratory parameters – obligatory laboratory tests. Small blood count [thrombocytopenia?] Differential blood count Coagulation parameters – bleeding time, PTT, Quick or INR. Determination of coagulation factors: VIII (hemophilia A), IX (hemophilia B), VWF (von Willebrand factor; synonyms: Clotting factor VIII-associated antigen or von Willebrand factor antigen, vWF-Ag). If necessary, other coagulation factors Laboratory … Bleeding Tendency: Lab Test
