What if a potential donor is tissue compatible? If the tissue characteristics of the registered person match those of an affected person, the German Bone Marrow Donor Center (DKMS) contacts the donor. The further procedure includes a health check and a renewed HLA typing, the so-called confirmatory typing (CT). The health questionnaire sent out serves … What if a potential donor is tissue compatible? | Bone Marrow Donation
Bone marrow donation procedure The required hematopoietic stem cells are primarily located in the iliac crest. Currently, there are two ways to obtain the desired hematopoietic stem cells. Here, a peripheral collection of hematopoietic stem cells and the classic bone marrow donation have to be distinguished from each other. As a rule, a donor must … Bone marrow donation procedure | Bone Marrow Donation
Possible complications The risk for the donor in the course of a bone marrow donation is low and, in the case of classic bone marrow donation, is largely the anaesthetic risk that every anaesthetic performed involves. The insufficient differentiation between bone marrow and spinal cord is widespread. Since the spinal cord plays no role at … Possible complications | Bone Marrow Donation
Definition People who can benefit from a bone marrow donation are patients with leukemia, also known generally as blood cancer, such as acute myeloid leukemia or acute lymphocytic leukemia. In the course of bone marrow donation, blood stem cells (hematopoietic stem cells) are passed on. Their location is primarily in the bone marrow, where the … Bone Marrow Donation
Bone Marrow Donation For the allogeneic transplantation just described, people are needed who agree to donate bone marrow. In the search for a suitable bone marrow donor, one can reach the goal in three different ways. The highest probability of finding a suitable donor is among siblings, it is about 25%. This type of search … Bone Marrow Donation | Bone Marrow Donation
Definition – What is the HLA? In medicine, the abbreviation HLA stands for Human Leukocyte Antigen. The HLA are a group of molecules consisting of a protein portion and a carbohydrate portion. Therefore they are called glycoprotein. The HLA are found on the surface of every single body cell and also on the surfaces of … HLA – Human Leukocyte Antigen
Procedure for HLA determination HLA can be determined in four different ways. In each case, tissue from both donor and recipient is required. The exact determination of the structure of the HLA is done with the so-called antigen determination. The process of the polymerase chain reaction (PCR) is used for this. In this process cells … Procedure for HLA determination | HLA – Human Leukocyte Antigen
Evaluation of the HLA values The costs of a typing are about 50€. If the typing has to be very detailed, the costs can be higher. In the last years the effort and therefore the costs could be reduced strongly by the mechanical evaluation. All articles in this series: HLA – Human Leukocyte Antigen Procedure … Evaluation of the HLA values | HLA – Human Leukocyte Antigen
Leukemia, white blood cancer, capers, blood disease Definition This type of leukaemia is one of the acute leukaemias with a rapid course of disease. It is characterised by the fact that the degenerated cells originate from a very early stage of development, i.e. they are immature. These cells develop from a cell line that originates … Acute myeloid leukaemia (AML)
Symptoms Increased night sweats, fever, weight loss, loss of appetite, performance slump and bone pain occur. In addition, anaemia occurs; its symptoms are paleness of the skin, a performance kink, rapid heartbeat (tachycardia) and rarely even tightness of the chest (angina pectoris). The suppressive growth of the degenerated cells results in a lack of “normal” … Symptoms | Acute myeloid leukaemia (AML)
What happens if you do not do therapy/treatment? Like all acute leukemias, AML is characterized by a very aggressive course of the disease. Untreated, it leads to death within a few weeks. It is therefore extremely important that treatment is started immediately after a rapid diagnosis. If a decision were now to be made against … What happens if you do not do therapy/treatment? | Acute myeloid leukaemia (AML)
Definition Lymphomas are malignant diseases of the human lymphatic system, which usually spread throughout the entire body via the lymph fluid and malignantly alter the intermediate lymph nodes. Causes and forms Lymphomas/lymphomas are divided into two different groups: Hodgkin lymphomas (also known as Hodgkin’s disease) and non-Hodgkin’s lymphomas (NHL). Hodgkin’s lymphoma, which is also called … Lymphoma
