Products
Hexetidine is commercially available as a solution and spray and has been approved in many countries since 1966 (original: Hextril; Drossadin). Furthermore, vaginal tablets are also available (Vagi-Hex). This article refers to use in the mouth and throat.
Structure and properties
Hexetidine (C21H45N3, Mr = 339.6 g/mol) exists as a colorless to faint yellow oily liquid that is very sparingly soluble in water. It is a 1,3-diazinane derivative.
Effects
Hexetidine (ATC A01AB12) has antibacterial, antifungal, antiviral, weak local anesthetic, and deodorant properties. It has a high affinity for mucous membranes and is therefore effective for a long time, over 10 to 12 hours.
Indications
Hexetidine is used primarily for inflammatory and infectious diseases of the mouth and throat. Indications include:
- Tonsillitis
- Pharyngitis, sore throat
- Inflammation of the tongue
- Additional medication for streptococcal angina.
- Pre- and post-treatment for tonsillectomy (tonsil operation)
- Injuries to the mouth and throat
- Gum inflammation
- Bleeding gums
- Oral mucositis
- Aphthae
- Bad breath
- Oral hygiene in severe general diseases
In some countries also for fungal infections of the oral cavity.
Dosage
According to the package leaflet. The spray and solution are usually applied twice daily after meals. The solution may also be applied locally. The solution should not be swallowed, but spit out. Do not inhale while using the spray.
Contraindications
- Hypersensitivity
- Children and adolescents (no data, depends on country).
For full precautions, see the drug label.
Interactions
Hexetidine is inactivated by soaps and anionic substances found in toothpastes.
Adverse effects
Adverse effects occur rarely to very rarely. Possible side effects include:
