Hormonal contraceptives (birth control pills) can increase or decrease the efficacy or bioavailability of medications by affecting
- The uptake (absorption disorders)
- of metabolism
Knowledge of these actions or interactions have a special weight from the point of view of contraception protection and potential teratogenic (malformation-promoting) hazards.For detailed assistance on this important issue, please refer to the long version of the 2019 guidelines.
- P. 171 ff, in particular the tabular listing and the recommendations for use contained therein.
- Pg 179 ,Tab.22: Drugs that reduce the efficacy of hormonal contraceptives.
- Drugs: antacids, antibiotics, antiepileptic drugs, HIV drugs, emergency contraception (ulipristal acetate), H2 receptor antagonists, proton pump inhibitors (proton pump inhibitors, acid blockers).
- Medicinal plants: St. John’s wort, bosentan, modafinil, aprepitant, sugammadex.
- Pg 182, Table 23: Drugs affected by combined oral contraceptives (COCs; contraceptives containing estrogen and progestin):
- Aldosterone antagonists, antidiabetics, antiepileptics, antihypertensives, antifungals, anxiolytics, bronchodilators, diuretics, dopaminergics, hypnotics, immunosuppressants, potassium-sparing diuretics, muscle relaxants, retinoids, thyroid hormones, triptans.
- Pg 183, Tab.24: Recommendations for contraceptive use with concomitant use of enzyme-inducing drugs.
- Combined hormonal contraceptives (oral, transdermal (“through the skin“), vaginal).
- Progestin monotherapy (oral, implant (hormonal implant; contraceptive sticks), intramuscular/”into the muscle”)
- Emergency contraception
