Therapeutic target
Improvement of symptomatology
Therapy recommendations
- Initiation of testosterone therapy when:
- The clinical symptoms make it necessary and.
- Serum levels fall below the normal limit of 12 nmoL/L total testosterone and/or 250 pmoL/L free testosterone
Indication of clinical symptoms and testosterone levels are:
- Loss of libido and drive: < 15 nmol/L.
- Hot flashes and erectile dysfunction (ED; erectile dysfunction): < 8 nmol/L
- See also under “Other therapy.”
Cave From a substitution therapy should be refrained from if there is a desire to have children, because testosterone suppresses a residual spermatogenesis (residual sperm cell formation)! By means of TESE (TEsticular sperm extraction; extraction of sperm from the testis) in combination with ICSI (Intracytoplasmic sperm injection; insertion of a single sperm / sperm cell with the help of a microcapillary directly into an egg) can now be achieved in individual cases paternity.
