Products
Mebeverine is commercially available in the form of sustained-release capsules (Duspatalin Retard). It has been approved in many countries since 1967.
Structure and properties
Mebeverine (C25H35NO5, Mr = 429.6 g/mol) is an open-chain derivative of papaverine. It is present in drugs as mebeverine hydrochloride, a white crystalline powder that is very soluble in water.
Effects
Mebeverine (ATC A03AA04) has muscle relaxant and antispasmodic properties in the gastrointestinal tract and biliary tract. It is selectively effective on smooth muscle. Unlike other spasmolytics, it is not anticholinergic
Indications
For symptomatic treatment of pain and abdominal cramps associated with functional complaints of the digestive tract and biliary tract. It is used, for example, in irritable bowel syndrome.
Dosage
According to the professional information. The capsules are taken in the morning and evening.
Contraindications
- Hypersensitivity
- Paralytic intestinal obstruction
For complete precautions, see the drug label.
Interactions
There are no known drug-drug interactions.
Adverse effects
Possible adverse effects include hypersensitivity reactions, dizziness, lightheadedness, confusion, nausea, angioedema, hives, and other skin rashes.
