Products
Milrinone is commercially available as a solution for injection (Corotrope, generic). It was approved in many countries in 1992.
Structure and properties
Milrinone (C12H9N3O, Mr = 211.22 g/mol) is a bipyridine derivative and a carbonitrile derivative of amrinone.
Effects
Milrinone (ATC C01CE02) has positive inotropic and vasodilatory properties. The effects are due to inhibition of phosphodiesterase III.
Indications
For short-term intravenous treatment of heart failure.
Dosage
According to the SmPC. Milrinone is injected intravenously and administered as an infusion.
Contraindications
For complete precautions, see the drug label.
Interactions
There are no known drug-drug interactions to date.
Adverse effects
The most commonly observed adverse effects include headache and cardiovascular disturbances such as arrhythmias, low blood pressure, and angina. Occasional occurrences include: Thrombocytopenia, hypokalemia, tremor, altered liver enzymes. Very rarely, torsades de pointe, bronchospasm, skin reactions including local reactions at the injection site, anaphylactic shock.
