Oral Thrush (Gingivostomatitis Herpetica): Or something else? Differential Diagnosis

Blood, blood-forming organs-immune system (D50-D90).

Endocrine, nutritional and metabolic diseases (E00-E90).

  • Folic acid deficiency
  • Vitamin B12 deficiency

Skin and subcutaneous tissue (L00-L99)

  • Bullous erythema exsudativum multiforme (synonym: dermatostomatitis Baader, Fiessinger-Rendu syndrome, erythema exsudativum multiforme majus) – infectious or drug allergic skin disease.
  • Erosive (superficial tissue loss of the skin / mucosa) lichen ruber planus (nodular lichen).
  • Pemphigoid (blistering skin disease).
  • Pemphigus (blistering skin disease).

Infectious and parasitic diseases (A00-B99).

  • Angina Plaut-Vincent – relatively rare form of tonsillitis (inflammation of the tonsils) with pseudomembranous ulceration (ulceration) of the pharynx and tonsils (adenoids).
  • Candidiasis (fungal disease)
  • Hand-foot-mouth disease (HFMK; hand-foot-mouth exanthema) [most common cause: Coxsackie A16 viruses].
  • Herpangina (synonym: Zahorsky’s disease) – occurs predominantly in childhood; affects the oral mucosa and palatine tonsil; it is caused by infection with Coxsackie virus (type A)
  • Herpes zoster (shingles)
  • HIV infection
  • Infections caused by other pathogens such as Varicella zoster or bacteria.
  • Mononucleosis (Pfeiffer’s glandular fever)
  • Syphilis (lues; venereal disease)
  • Tuberculosis (consumption)

Mouth, esophagus (esophagus), stomach, and intestines (K00-K67; K90-K93).

  • Ulcerative colitis – chronic inflammatory disease of the mucosa of the colon (large intestine) or rectum (rectum).
  • Crohn’s disease – chronic inflammatory bowel disease; it usually progresses in episodes and can affect the entire digestive tract; characteristic is the segmental affection of the intestinal mucosa (intestinal mucosa), that is, several intestinal sections may be affected, which are separated from each other by healthy sections
  • Recurrent (recurrent) aphthous ulceration.
  • Celiac disease (gluten-induced enteropathy) – chronic disease of the mucosa of the small intestine (small intestinal mucosa) due to hypersensitivity to the cereal protein gluten.

Musculoskeletal system and connective tissue (M00-M99).

  • Behçet’s disease (synonym: Adamantiades-Behçet’s disease; Behçet’s disease; Behçet’s aphthae) – multisystem disease of the rheumatic type associated with recurrent, chronic vasculitis (vascular inflammation) of the small and large arteries and mucosal inflammation; The triad (the occurrence of three symptoms) of aphthae (painful, erosive mucosal lesions) in the mouth and aphthous genital ulcers (ulcers in the genital region), as well as uveitis (inflammation of the middle eye skin, which consists of the choroid (choroid), the ray body (corpus ciliare) and the iris) is stated as typical for the disease; a defect in cellular immunity is suspected

Neoplasms – tumor diseases (C00-D48).

  • Malignant neoplasm of the salivary gland.
  • Leukemia (blood cancer)
  • Squamous cell carcinoma – malignant neoplasm of skin / mucosa.

Further

  • Trauma (injuries)