Products
Pancreatin is commercially available in the form of capsules, dragées, and tablets (Combizym, Creon, Panzytrat).
Structure and properties
Pancreatin (pancreatic powder) is obtained from the fresh or frozen pancreas of mammals, such as pigs or cattle. The substance contains digestive enzymes with proteolytic, lipolytic and amylolytic activity. Pancreatin is a faint brown, amorphous powder with a peculiar odor, which is partially soluble in water. It is acid-sensitive and therefore must be administered in the form of gastric acid-resistant drugs or in combination with a proton pump inhibitor.
Effects
Pancreatin (ATC A09AA02) is used to substitute digestive enzymes of the exocrine pancreas. These include proteases (e.g., trypsin, chymotrypsin), amylases, and lipases. These enzymes enable the digestion of carbohydrates, proteins, and lipids and the absorption of food components into the bloodstream and body.
Indications
For the treatment of digestive symptoms, e.g., bloating and flatulence, and for hypofunction of the pancreas (pancreatic insufficiency), e.g., cystic fibrosis, chronic pancreatitis, pancreatectomy, and gastrectomy. Pancreatic insufficiency is seen in up to 85% of patients with cystic fibrosis.
Dosage
According to the SmPC. Medicines are taken during meals with adequate water. Do not chew, otherwise the mucous membrane of the mouth may be damaged.
Contraindications
- Hypersensitivity
- Acute pancreatitis (inflammation of the pancreas)
Full precautions can be found in the drug label. Not suitable for vegetarians or vegans.
Interactions
Pancreatin may potentially decrease folic acid absorption. Folic acid substitution may be indicated. Furthermore, the blood glucose-lowering effects of acarbose and miglitol may be reduced.
Adverse effects
Possible adverse effects include hypersensitivity reactions (eg, rash, bronchospasm), digestive disturbances, fibrosing colonopathy, and hyperuricemia.
