Products Ocriplasmin is commercially available as an injectable (Jetrea). It has been approved in many countries since 2014. Structure and properties Ocriplasmin is a recombinant and truncated derivative of the human proteolytic enzyme plasmin with a molecular weight of 27.2 kDa. It is produced by biotechnological methods. Effects Ocriplasmin (ATC S01XA22) has proteolytic properties on … Ocriplasmin
Products Lysozyme is mainly commercialized in medicines for sore throat, e.g., Lysopain and Sangerol. Structure and properties Lysozyme is an endogenous mucopolysaccharidase (protein, enzyme) found in saliva and elsewhere. It is composed of 129 amino acids. Effects Lysozyme (ATC A01AB11) has bactericidal, antiviral, and anti-inflammatory properties. Indications Acute inflammatory conditions of the mouth and throat, … Lysozyme
Products Elosulfase alfa was approved in the EU and US in 2014 and in many countries in 2016 as a concentrate for the preparation of an infusion solution (Vimizim). Structure and properties Elosulfase alfa is the recombinant form of the human enzyme -acetylgalactosamine-6-sulfatase. It is produced by biotechnological methods. Effects Elosulfase alfa (ATC A16AB12) replaces … Elosulfase Alfa
Products Pegvaliase was approved in the United States in 2018 as an injectable (Palynziq). The drug is not yet registered in many countries. Structure and properties Pegvaliase is a phenylalanine-metabolizing enzyme consisting of recombinant phenylalanine ammonia lyase conjugated to -hydroxysuccinimide methoxy polyethylene glycol. The gene of the enzyme is derived from cyanobacterium . According to … Pegvaliase
Products Pegaspargase is commercially available as an injectable (Oncaspar). The drug was approved in the United States in 2006, in the EU in 2016, and in many countries in 2017. Structure and properties Pegaspargase (PEG-L-asparaginase) is the pegylated enzyme L-asparaginase. The PEG units are covalently attached to the enzyme. Effects Pegaspargase (ATC L01XX24) has antileukemic … Pegaspargases
Products Pegloticase is commercially available as a concentrate for the preparation of an infusion solution (Krystexxa). The drug is not currently registered in many countries. Structure and properties Pegloticase is a recombinant uricase conjugated to mPEG (monomethoxypolyethylene glycol). It is obtained from genetically modified using biotechnological methods. The active ingredient has a molecular weight of … Pegloticase
Products Bromelain was commercially available in many countries in the form of dragées (Traumanase), and dietary supplements containing pineapple powder are available. Other drugs are approved abroad, for example, Wobenzym and Phlogenzym. Wobenzym is registered in many countries only in the canton of Appenzell Ausserrhoden. Structure and properties Bromelain is the name given to a … Bromelain Effects and Side Effects
Products Pancreatin is commercially available in the form of capsules, dragées, and tablets (Combizym, Creon, Panzytrat). Structure and properties Pancreatin (pancreatic powder) is obtained from the fresh or frozen pancreas of mammals, such as pigs or cattle. The substance contains digestive enzymes with proteolytic, lipolytic and amylolytic activity. Pancreatin is a faint brown, amorphous powder … Pancreatin
Products Papain is no longer included in Lysopain lozenges after the change in composition today. Stem plant Melon tree. Effects Papain is a proteolytic enzyme. Indications In combination for sore throat to cleanse and regenerate damaged mucosa.
Products Amylases are available, for example, in the form of capsules together with other digestive enzymes. They are often present in industrially produced bread and pastries. The enzymes‘ name is derived from (starch), which is their substrate. Structure and properties Amylases are natural enzymes that hydrolytically cleave glycosidic bonds. They belong to the class of … Amylases
Products Xylanases are found in baked goods such as breads as additives. Structure and properties Xylanases are natural enzymes found, for example, in microorganisms such as bacteria and fungi, from which they are also extracted. They degrade xylan, a polysaccharide (a carbohydrate) found in plants and grasses that belongs to the hemicelluloses. It consists of … Xylanases
Products Collagenase from is commercially available as a powder and solvent for the preparation of a solution for injection (Xiapex). It was approved in many countries in 2011. Sales of Xiapex were discontinued in 2020. Structure and properties It is a mixture of two collagenases AUX-I and AUX-II obtained by fermentation from the gas gangrene … Collagenase From Clostridium Histolyticum
