Synonyms in a broader sense Leukemia, white blood cancer, Philadelphia chromosome Definition CML (chronic myeloid lekemia) shows a chronic, i.e. rather slowly progressing course of the disease. This leads to the degeneration of a stem cell, which is a precursor of granulocytes in particular, i.e. cells that are important for the defence against mainly bacteria. … Chronic myeloid leukaemia (CML)
Chronic phase Most often, chronic myeloid leukaemia is discovered during the chronic phase. It corresponds to the initial stage of the disease and can last up to ten years. It often proceeds without symptoms, so that the initial diagnosis is often made rather coincidentally, e.g. in the context of a routine blood test by the … Chronic phase | Chronic myeloid leukaemia (CML)
Prognosis/life expectancy/healing chances According to the current state of science, chronic myeloid leukaemia cannot be cured with medication. In cases of advanced disease or lack of response to therapy, a bone marrow transplantation, which is curative in principle (i.e. promising to cure) but risky, can be considered. Therefore, it is not so easy to make … Prognosis/life expectancy/healing chances | Chronic myeloid leukaemia (CML)
Symptoms The possible signs and symptoms of chronic myeloid leukemia include: Fatigue Feeling sick Bleeding tendency Susceptibility to infectious diseases Lack of appetite, digestive problems, weight loss. Fever Night sweats Enlargement of the spleen and liver, pain. Disorders of hematopoiesis, bone marrow changes Pale skin In the bone marrow and blood, a strong proliferation and … Chronic Myeloid Leukemia
Synonyms Tyrosine kinase inhibitors include : imatinib, sunitinib, midostaurine and many others Introduction Tyrosine kinase inhibitors are also known as tyrosine kinase inhibitors. This is a group of drugs that inhibit the enzyme tyrosine kinase, which is involved in the development, survival and spread of cancer in the body. Tyrosine kinase inhibitors, such as the … Targeted cancer therapy with tyrosine kinase inhibitors
Side effects Tyroin kinase inhibitors are highly potent drugs. Their use can lead to side effects that do not necessarily occur in every patient. In some cases, these can be serious to life-threatening, which is why a doctor should be consulted immediately. In general, treatment with tyrosine kinase inhibitors requires close monitoring of symptoms and … Side effects | Targeted cancer therapy with tyrosine kinase inhibitors
Interaction Tyrosine kinase inhibitors, like many other drugs, are metabolised and broken down by certain enzymes in the liver. Thus, many drugs can influence the effect of tyrosine kinase inhibitors, but tyrosine kinase inhibitors can also influence other drugs. The effect can be enhanced, which is associated with an increased risk of side effects; or … Interaction | Targeted cancer therapy with tyrosine kinase inhibitors
Price Tyrosine kinase inhibitors are active ingredients from the group of genetically engineered monoclonal antibodies. This newer, targeted treatment of cancer is still very expensive. As a rule, it is a long-term or even life-long therapy to suppress a relapse. Glivec (contains the active ingredient Imatinib) in the therapy of chronic myeloid leukemia costs over … Price | Targeted cancer therapy with tyrosine kinase inhibitors
