In addition to the medical history and skin symptoms, laboratory findings of blood and tissue are important, among other things. For this purpose, it is beneficial to distinguish between progressive systemic scleroderma and circumscritic scleroderma. Expressions of scleroderma. In progressive systemic scleroderma, certain proteins of the defense system (antinuclear antibodies) are found in the blood, … Scleroderma: Diagnosis and Treatment
Scleroderma is an autoimmune disease. It is an inflammatory rheumatic disease that belongs to the collagenoses. The disease is characterized by progressive hardening of the connective tissue. Initially, the fingertips become discolored only temporarily. Then the skin on the hands, feet and face thickens, becomes hard and brittle. Later, the changes spread to the arms, … Scleroderma: Development and Causes
The appearance is highly variable and depends on the form of progression. A distinction is made between the circumscritic (= localized, circumscribed) form, which affects only the connective tissue of the skin and is also referred to as morphaea, and progressive systemic scleroderma, which – to a very different extent – also involves the connective … Scleroderma: Forms and Symptoms
