Effects Iron chelators form complexes with iron ions and deliver them to excretion as a complex. Indications Chronic iron overload T.T. chronic aluminum overload Acute iron poisoning Hemosiderosis (iron deposition in the form of hemosiderin). Agents Deferoxamine (Desferal) Deferiprone (Ferriprox) Deferasirox (Exjade)
Most common mechanism of action Most drugs bind to a macromolecular target structure called a drug target. These are usually proteins such as receptors, transporters, channels, and enzymes, or nucleic acids. For example, opioids interact with endogenous opioid receptors to relieve pain. Targets can also be exogenous structures. Penicillins inhibit bacterial enzymes responsible for building … Mechanism of Action
Products Deferiprone is commercially available in the form of film-coated tablets (Ferriprox, generic). It was approved in many countries in 2001. Structure and properties Deferiprone, or 3-hydroxy-1,2-dimethylpyridin-4-one (C7H9NO2, Mr = 139.2 g/mol) is a methylated and hydroxylated pyridinone derivative. It belongs to the α-ketohydroxypyridones. Deferiprone exists as a white to pink crystalline powder that is … Deferiprone
Products Deferoxamine is commercially available as an injectable (Desferal). It has been approved in many countries since 1963. Structure and properties Deferoxamine is present in drugs as deferoxamine mesilate (C26H52N6O11S, Mr = 657 g/mol), a white powder that is readily soluble in water. Effects Deferoxamine (ATC V03AC01) forms complexes with trivalent iron and aluminum and … Deferoxamine
