dopamine agonist

Apomorphine: Effect, Medical Applications, Side Effects

How apomorphine works Apomorphine mimics the neurotransmitter dopamine in the central nervous system and binds to its docking sites (receptors). In this way, the active ingredient mediates the effects typical of dopamine. Parkinson’s disease: In Parkinson’s disease, nerve cells that produce and secrete dopamine gradually die. The use of apomorphine can therefore be helpful. However, … Apomorphine: Effect, Medical Applications, Side Effects

Quinagolide

Products Quinagolide is commercially available in tablet form (Norprolac). It has been approved in many countries since 1994. Structure and properties Quinagolide (C20H33N3O3S, Mr = 395.56 g/mol) is a non-ergoline dopamine agonist with a similar structure to apomorphine. It is present in drugs as quinagolide hydrochloride. Effects Quinagolide (ATC G02CB04) has dopaminergic properties and inhibits … Quinagolide

Metergolin

Products Metergoline is commercially available in the form of tablets for animals. It has been approved in many countries since 1990. Structure and properties Metergoline (C25H29N3O2, Mr = 403.5 g/mol) is a synthetic ergoline derivative. Effects Metergoline (ATCvet QG02CB05) has antiserotoninergic properties and inhibits prolactin secretion. The effects are due to antagonism at serotonin 5HT … Metergolin

Lisuride: Effects, Uses & Risks

The drug Lisuride belongs to the drug class of dopamine agonists. It also belongs to the serotonin antagonists and to the HT2B antagonists. What is lisuride? Mainly, the drug lisuride is used in the therapy of Parkinson’s disease. The ergoline derivative lisuride is used for various indications. However, the drug is mainly used in the … Lisuride: Effects, Uses & Risks

Mastopathy: Causes, Symptoms & Treatment

Mastopathy is the benign change of glandular tissue in the female breast. Symptoms include swelling and tightness in the breast, often associated with menstruation, or palpable lumps and cysts in the breast. What is mastopathy? Palpate mastopathy in the breast. Mastopathy – also called mammary dysplasia – describes changes in the glandular body of the … Mastopathy: Causes, Symptoms & Treatment

Single Dose

Single administration Many medications are administered daily over a long period of time, such as agents for high blood pressure or lipid-lowering agents such as statins for disorders of lipid metabolism. However, various drugs also exist for which a single dose, i.e., a single administration, is sufficient. If necessary, it can be repeated after a … Single Dose

Phenothiazines: Effects, Uses & Risks

Phenothiazines are a subgroup of thiazines. They are used primarily as neuroleptics. What are phenothiazines? Phenothiazines are derivatives of phenothiazine that are of pharmacologic relevance. In medicine, they are used as neuroleptics. There they are also known as tricyclic neuroleptics. The history of phenothiazines can be traced back to the beginning of organic chemistry. In … Phenothiazines: Effects, Uses & Risks

Rotigotine: Effects, Uses & Risks

The drug rotigotine belongs to the group of non-ergoline dopamine agonists and is used in the therapy of restless legs syndrome or Parkinson’s disease. What is rotigotine? Rotigotine is a so-called aminotetroline and tiophene derivative that is very similar to dopamine. It is liptophilic and has an extremely low molecular weight, so it is well … Rotigotine: Effects, Uses & Risks

Ropinirole

Products Ropinirole is commercially available in the form of film-coated tablets (Adartrel, Requip, generic). It has been approved in many countries since 1996. Structure and properties Ropinirole (C16H24N2O, Mr = 260.4 g/mol) is a non-ergoline dopamine agonist and a dihydroindolone derivative. It is present in drugs as ropinirole hydrochloride, a white to yellow powder that … Ropinirole

Prolactin: Function & Diseases

Prolactin (PRL) is a hormone produced in the lactotropic cells in the anterior pituitary gland. It is especially important during the period of pregnancy and during breastfeeding. Several diseases may be related to prolactin. What is prolactin? Schematic diagram showing the anatomy and structure of the endocrine (hormone) system. Click to enlarge. Prolactin, or lactotropic … Prolactin: Function & Diseases

Pergolide: Effects, Uses & Risks

Pergolide is an active ingredient isolated from naturally occurring fungal alkaloids and is approved as a therapeutic agent for Parkinson’s disease. It is also used in veterinary medicine for the treatment of an equine disease. Pergolide acts on the receptors of the neurotransmitter dopamine. What is pergolide? Pergolide drugs are used as a monopreparation for … Pergolide: Effects, Uses & Risks