esketamine

Esketamine: Mode of Action, Side Effects

How esketamine works Esketamine primarily has analgesic, narcotic and antidepressant effects. It can also stimulate the circulation and increase saliva production, for example. Analgesic and narcotic effects of esketamine. Esketamine mediates its main effect by blocking the so-called N-methyl-D-aspartate receptors (NMDA receptors for short) and reversibly switching off consciousness. NMDA receptors are docking sites of … Esketamine: Mode of Action, Side Effects

Ketamine: Drug Effects, Side Effects, Dosage and Uses

Products Ketamine is commercially available as a solution for injection (Ketalar, generic). It has been approved in many countries since 1969. Esketamine nasal spray was approved in 2019 (Switzerland: 2020) for the treatment of treatment-resistant depression (see there). Structure and properties Ketamine (C13H16ClNO, Mr = 237.7 g/mol) is a cyclohexanone derivative derived from phencyclidine (“angel … Ketamine: Drug Effects, Side Effects, Dosage and Uses