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Complications of erysipelas Complications rarely occur in cases of erysipelas. These can occur if there is insufficient or no therapy. In this case the inflammation can spread to deeper tissues, which can lead to life-threatening complications. For example, erysipelas can lead to phlebitis, blood poisoning (sepsis), purulent inflammation (phlegmon), bacterial heart inflammation (endocarditis) and acute … Complications of erysipelas | Erysipelas causes and symptoms