Methotrexate and folic acid Methotrexate is an active substance that acts as an antagonist of folic acid in the body (a so-called folic acid antagonist). Folic acid or vitamin B9 is important for cell division, in particular it plays a role in the production of building blocks of the genetic material (DNA). So if the … Methotrexate and folic acid | Methotrexate
How do immunosuppressants work? Each group of immunosuppressive drugs unfolds its efficacy in a different way. The glucocorticoids unfold their effect by binding via a receptor (NF-kB) located in the cell, which prevents the reading of DNA. As a result, pro-inflammatory proteins and messenger substances of the inflammatory reaction or the immune response can no … How do immunosuppressants work? | Immunosuppressive drugs
Effect of Methotrexate Methotrexate is an active ingredient used in the treatment of chronic inflammatory diseases and various types of cancer. Methotrexate has three important effects: it has antineoplastic, immunosuppressive and anti-inflammatory effects. Antineoplastic means that methotrexate is effective against malignant tumors (neoplasia). Substances that have an antineoplastic effect belong to the group of cytostatic … Effect of Methotrexate | Methotrexate
What should be considered when discontinuing immunosuppressive drugs? Immunosuppressive drugs are often taken over very long periods of time. Organ transplanted patients must take immunosuppressive drugs throughout their lives to avoid rejection after years. Due to the severe side effects of immunosuppressive drugs, many patients are unwilling to take the medication. In the worst case, … What should be considered when discontinuing immunosuppressive drugs? | Immunosuppressive drugs
Methotrexate and alcohol The active ingredient methotrexate is used to treat chronic rheumatic diseases. Since it is a highly dangerous drug, improper handling of Methotrexate can be harmful to health and the greatest care is required during use. In addition to undesirable effects of Methotrexate such as nausea and vomiting, kidney and liver damage are … Methotrexate and alcohol | Methotrexate
Immunosuppressants for the treatment of Crohn’s disease Crohn’s disease is a chronic inflammatory disease that can affect the entire gastrointestinal tract. The following immunosuppressive drugs are used to treat an acute attack: Budesonide, mesalazine and possibly prednisolone. Budesonide is a glucocorticoid that is metabolised to a large extent in the liver. It therefore has mainly … Immunosuppressants for the treatment of Crohn’s disease | Immunosuppressive drugs
Liver diseases caused by methotrexate and alcohol The risk of liver and biliary disease can occur under therapy with methotrexate. This is especially true when methotrexate is used for more than two years and the total dose is more than 1.5 grams of methotrexate. The risk of this is even greater if alcohol is consumed … Liver diseases caused by methotrexate and alcohol | Methotrexate
Immunosuppressive drugs for the treatment of multiple sclerosis Multiple sclerosis is an inflammatory, autoimmune nerve disease in the course of which the protective layer around the nerve fibers (myelin layer) is increasingly destroyed. MS progresses in phases, i.e. intervals of almost complete freedom from pain alternate with strong attacks of the disease. Especially during the … Immunosuppressive drugs for the treatment of multiple sclerosis | Immunosuppressive drugs
CREST syndrome is the name given to a particular form of systemic scleroderma. It is one of the autoimmune diseases. What is CREST syndrome? CREST syndrome is a collagenosis. It is considered a specific form of progressive systemic scleroderma. The autoimmune disorder is also known as Thibierge-Weissenbach syndrome or limited systemic scleroderma. The term CREST … CREST Syndrome: Causes, Symptoms & Treatment
Introduction A number of illnesses make it necessary to take methotrexate. Especially if NSAIDs (non-steroidal anti-inflammatory drugs) are not responded to, methotrexate therapy may be indicated. However, methotrexate can also be used to treat active rheumatoid arthritis or severe forms of psoriasis. Methotrexate belongs to the group of active ingredients of specific antirheumatic drugs and … Side effects of Methotrexate
Side effect hair loss Hair loss is a rare but possible consequence of taking medication. However, there are a number of possible causes of hair loss, so it could be a coincidence if hair loss occurs while taking Methotrexate. If a connection is probable, it should be considered in consultation with the doctor: If the … Side effect hair loss | Side effects of Methotrexate
Fertility and pregnancy under methotrexate Methotrexate has a teratogenic effect, i.e. it damages the embryo or the “maturing fruit”, if one wants to translate the term literally. Therefore, methotrexate therapy is not possible during pregnancy. It can lead to hereditary damage to the embryo, and in the worst case to abortion. Even after discontinuing methotrexate … Fertility and pregnancy under methotrexate | Side effects of Methotrexate
