Products Calcifediol was approved in the United States in 2016 and in many countries in 2020 in extended-release capsule form (Rayaldee). Structure and properties Calcifediol (C27H44O2, Mr = 400.6 g/mol) is a hydroxylated derivative of vitamin D3 (cholecalciferol). It is 25-hydroxycholecalciferol or 25-hydroxyvitamin D3. Calcifediol is present in the drug as calcifediol monohydrate, a white … Calcifediol
Structure and properties Polypeptide composed of 84 amino acids Synthesis and release Formation in the parathyroid glands Effects Bone resorption by activation of osteoclasts: increase in blood calcium levels Effect on kidney: Decrease in phosphate reabsorption: decrease in blood phosphate level. Decrease in calcium excretion: increase the level of calcium in the blood. Stimulation of … Parathyroid Hormone
Definition One speaks of a Vitamin D deficiency if the physiological need for Vitamin D cannot be sufficiently covered. As standard value a Vitamin D mirror of 30 μg/l is accepted. Straight one in Germany lies the Vitamin D mirror however far under 20μg/l. Values between 10-20μg/l are referred to as a manifest vitamin D … Vitamin D deficiency
Causes The most common cause of vitamin D deficiency is insufficient intake of vitamin D from food, or insufficient formation of vitamin D by sunlight. This occurs particularly in the dark autumn and winter months. Dark skinned people living in Germany are also particularly often affected by a vitamin D deficiency, as their dark skin … Causes | Vitamin D deficiency
Pathophysiology – what happens when there is a vitamin D deficiency Vitamin D is formed from the precursor cholecalciferol, which is either taken in with food or formed by sunlight. This cholecalciferol then undergoes several reactions in the liver and kidneys until it is formed into the active vitamin D (also called calcitriol). In this … Pathophysiology – what happens when there is a vitamin D deficiency | Vitamin D deficiency
Diagnostics In order to clarify a vitamin D deficiency, a blood test is carried out by a doctor. This should be carried out if there are already manifest signs of a vitamin D deficiency or if a vitamin D deficiency is suspected. This is necessary for example with concerning, which exhibit a decreased bone density, … Diagnostics | Vitamin D deficiency
