Renin-Angiotensin-Aldosterone System (RAAS): Significance

What is the renin-angiotensin-aldosterone system? The renin-angiotensin-aldosterone system (RAAS, often improperly called the RAAS system) controls the water and electrolyte balance of our organism and thus has a decisive effect on blood pressure: Since the functioning of our circulatory system depends on precise regulation of blood volume, mechanisms are required to balance the volume of … Renin-Angiotensin-Aldosterone System (RAAS): Significance

ACE Inhibitors List, Effects, Side Effects

Products Most ACE inhibitors are commercially available in the form of tablets and film-coated tablets. The first agent from this group to be approved was captopril, in many countries in 1980. ACE inhibitors are often combined with the thiazide diuretic hydrochlorothiazide (HCT) fix. Structure and properties ACE inhibitors are peptidomimetics derived from peptides found in … ACE Inhibitors List, Effects, Side Effects

Sartans

Products Most sartans are commercially available as tablets or film-coated tablets. Losartan was the first agent approved in many countries in 1994 (Cosaar, USA: 1995, Cozaar). Sartans are often combined with hydrochlorothiazide fix. The name of the drug group is derived from the suffix -sartan of the active ingredients. The drugs are also called angiotensin … Sartans

Valsartan

Products Valsartan is commercially available in the form of film-coated tablets and has been approved since 1996 (Diovan, generic). The active ingredient is also combined fixed with other agents: Hydrochlorothiazide (co-Diovan, Exforge HCT with amlodipine, generics). Amlodipine (Exforge, generic). Sacubitril (Entresto) Valsartan scandal: in July 2018, numerous generic drugs had to be recalled from the … Valsartan

Renin-Angiotensin-Aldosterone System (RAAS)

Effects The RAAS is activated in the presence of low blood pressure, decreased blood volume, hyponatremia, and sympathetic activation. Main actions: mediated via angiotensin II: Vasoconstriction Blood pressure increase Release of catecholamines Hypertrophy at the heart Mediated via aldosterone: Water and sodium ions are retained Potassium ions and protons are eliminated Overview of the RAAS … Renin-Angiotensin-Aldosterone System (RAAS)

Aliskiren

Products Aliskiren is commercially available in the form of film-coated tablets (Rasilez, Rasilez HCT + hydrochlorothiazide). It was approved in many countries, in the EU and in the United States in 2007 (Other brand name: Tekturna). Note: Other combination preparations, e.g., with amlodpine (Rasilamlo), are no longer available. Structure and properties Aliskiren (C30H53N3O6, Mr = … Aliskiren

Atacand PLUS

Candesartan, candesartan cilexetil, angiotensin II receptor antagonists, hydrochlorothiazide, diuretic, antihypertensive, antihypertensiveAtacand PLUS® is a drug for the treatment of high blood pressure (hypertension) in adults. It is a combined preparation of the two active ingredients candesartan and hydrochlorothiazide. Candesartan dilates the blood vessels, while hydrochlorothiazide has a draining effect. Both lead to a decrease in … Atacand PLUS

Angiotensin 2

Angiotensin 2 is an endogenous hormone which belongs to the class of so-called peptide hormones. Peptide hormones (synonym: proteohormones) are built up from the smallest individual components, the amino acids, and are water-soluble (hydrophilic/lipophobic). Angiotensin 2 itself consists of a total of eight amino acids. Due to its water-soluble property, angiotensin 2 is not able … Angiotensin 2

Angiotensin 2 Action

As part of the so-called renin-angiotensin-aldosterone system (RAAS), angiotensin 2 exerts a considerable influence on the maintenance of many processes within the organism. Angiotensin 2 is a hormone produced by the body itself and belongs to the group of peptide hormones (proteohormones). All peptide hormones have in common that they are composed of small individual … Angiotensin 2 Action