Definition/Active substance The active ingredient simvastatin (Simvahexal® from Hexal) is a drug for lowering blood lipid levels. It belongs to the group of so-called HMG-CoA reductase inhibitors (pronouncedly called hydroxy-methylglutaryl coenzyme A reductase inhibitors). This enzyme plays a decisive role in the body’s fat metabolism, as it is essential for the formation of new cholesterol. … Simvastatin
Metabolization The main area of application for simvastatin (Simvahexal®) is mainly hypercholesterolemia, where elevated cholesterol levels are found in the blood. Hypercholesterolemia can be caused by an unhealthy lifestyle, but also by a family genetic predisposition. Another very important field of application is the prevention of cardiovascular diseases, which can be caused by certain diseases … Metabolization | Simvastatin
Interactions Interactions with other drugs occur, for example, when simvastatin (Simvahexal®) is taken at the same time as other fat-lowering drugs such as fibrates. This increases the risk of myopathy or rhabdomyolysis, which can also occur if only the dose of simvastatin is increased. This risk also increases if inhibitors of the enzyme CYP3A4 are … Interactions | Simvastatin
