Products Dapoxetine is commercially available in the form of film-coated tablets (Priligy). It has been approved in many countries since 2013. Structure and properties Dapoxetine (C21H23NO, Mr = 305.4 g/mol) is present in drugs as dapoxetine hydrochloride, a white powder with a bitter taste that is soluble in water. Dapoxetine is a naphthyloxyphenylpropanamine derivative. It … Dapoxetine
Products In many countries, no medicines containing milnacipran are registered. In other countries, film-coated tablets and capsules are available, for example Savella in the United States. Structure and properties Milnacipran (C15H22N2O, Mr = 246.4 g/mol) is present in the drug as milnacipran hydrochloride, a white crystalline powder that is readily soluble in water. It is … Milnacipran
Products Esketamine nasal spray was approved in the US and EU in 2019 and in many countries in 2020 (Spravato). Structure and properties –Ketamine is the pure -enantiomer of ketamine (C13H16ClNO, Mr = 237.7 g/mol). The racemate ketamine is a cyclohexanone derivative derived from phencyclidine (“angel dust”). It is a ketone and an amine and … Esketamine Nasal Spray
Products Reboxetine is commercially available in tablet form (Edronax). It has been approved in some European countries since 1997 and in many countries since 2000. Structure and properties Reboxetine (C19H23NO3, Mr = 313.4 g/mol) is a morpholine derivative with two chiral centers. It exists in the drug as a mixture of the ,- and ,-enantiomers. … Reboxetine
Products Lorcaserin is commercially available in the form of film-coated tablets (Belviq). It was approved in the United States on June 27, 2012. It is not currently registered in many countries. Structure and properties Lorcaserin (C 11 H 14 ClN, M r = 195.7 g/mol) is present in drugs as lorcaserin hydrochloride and hemihydrate, a … Lorcaserin
Products Selegiline was commercially available in tablet form (Jumexal, generic). The drug was available in many countries from 1985 to 2016. Structure and properties Selegiline (C13H17N, Mr = 187.28 g/mol) is present in drugs as selegiline hydrochloride, a white crystalline powder that is readily soluble in water. Effects Selegiline (ATC N04BD01) has indirect dopaminergic and … Selegiline
Products Atomoxetine is commercially available in capsule form and as a drinkable solution (Strattera, generics). It was approved in many countries in 2009. Structure and properties Atomoxetine (C17H21NO, Mr = 255.4 g/mol) is present in drugs as atomoxetine hydrochloride. It is structurally closely related to the SSRI fluoxetine (Fluctine, Prozac, generics), which was also developed … Atomoxetine
Products Maprotiline was commercially available in the form of dragées and as a solution for injection (Ludiomil). It had been approved in many countries since 1972 and was withdrawn from the market in 2011 (solution for injection) and 2014 (dragées) for commercial reasons. Structure and properties Maprotiline (C20H23N, Mr = 277.4 g/mol) is in the … Maprotiline
Introduction The so-called serotonin noradrenaline reuptake inhibitors (SNRI) are mainly drugs used in the treatment of depression. The most important active ingredients in this class of drugs are venlafaxine and duloxetine. The name refers to the ability of these drugs to exert their effect on both serotonin and noradrenalin levels in the central nervous system. … SNRI
Effect of SNRI As described above and as can be seen from the name, serotonin noradrenalin reuptake inhibitors (SNRI) inhibit the reuptake of serotonin and noradrenalin into the nerve cells. In order to understand this mechanism, one should consider the structure of a synapse, i.e. an interconnection point between two nerve cells. A synapse consists … Effect of SNRI | SNRI
When should SNRI not be given? SNRIs must not be used if an intolerance and allergic reaction to the active substance has occurred. The use of so-called MAOIs, the irreversible monoamine oxidase inhibitors, is also considered a strict contraindication.These are drugs used to treat depression or Parkinson’s disease. If taken at the same time or … When should SNRI not be given? | SNRI
SNRI during pregnancy Pregnancy and antidepressants are two closely interwoven topics, as numerous studies have shown that the incidence of depression is significantly higher among pregnant women and women in the puerperium than in the general population. The most important piece of advice regarding pregnancy during depression treatment is to tell your doctor that you … SNRI during pregnancy | SNRI
