Definition In drug therapy, “off-label use” refers to deviations from the officially approved specifications in the drug information leaflet of approved drugs that are ready for use. Frequently, this concerns the areas of application (indications). However, other changes also fall under the definition, for example with regard to the dose, duration of therapy, patient groups, … Off-Label Use
Four million people in Germany suffer from depression – and many sufferers perceive it as a flaw of which they should be ashamed. But depression is neither a mental illness nor a sign of personal weakness. It can affect anyone. Depression is an illness with clear causes, symptoms and treatment options. It affects feelings, thoughts … Depression: When the Soul Carries “Grief”
Products Triptans are mainly taken in the form of film-coated tablets and melting tablets. Some are also available as subcutaneous injectable solutions and nasal sprays. Suppositories are no longer commercially available in many countries. Sumatriptan (Imigran) was the first agent in this group to be approved in the United States in 1992 and in many … Triptans: Drug Effects, Side Effects, Dosage and Uses
Symptoms Menopausal symptoms are very individual and vary from woman to woman. The most common possible disorders include: Cycle irregularities, change in menstruation. Vasomotor disorders: Flushes, night sweats. Mood swings, irritability, aggressiveness, sensitivity, sadness, difficulty concentrating, anxiety, fatigue. Sleep disorders Changes in skin, hair and mucous membranes: hair loss, vaginal atrophy, vaginal dryness, dry skin, … Menopausal Symptoms
Products Dapoxetine is commercially available in the form of film-coated tablets (Priligy). It has been approved in many countries since 2013. Structure and properties Dapoxetine (C21H23NO, Mr = 305.4 g/mol) is present in drugs as dapoxetine hydrochloride, a white powder with a bitter taste that is soluble in water. Dapoxetine is a naphthyloxyphenylpropanamine derivative. It … Dapoxetine
Background That grapefruit juice can cause drug-drug interactions was discovered by chance in a clinical trial in 1989 and confirmed in an experiment by the same research group in 1991 (Bailey et al, 1989, 1991). This showed that simultaneous ingestion of grapefruit juice with the calcium channel blocker felodipine significantly increases the bioavailability of felodipine. … Interactions with Grapefruit Juice
Symptoms Postpartum depression is a mental illness that begins in women within the first few months after delivery. Depending on the source, onset is reported within 1 to 12 months after delivery. It manifests itself in the same symptoms as other depressions and lasts several weeks to months. Postpartum depression is common and affects between … Postnatal Depression: Causes and Treatment
Products Escitalopram is commercially available as film-coated tablets, drops, and meltable tablets (Cipralex, generic). It has been approved in many countries since 2001. Structure and properties Escitalopram (C20H21FN2O, Mr = 324.4 g/mol) is the active -enantiomer of citalopram. It is present in drugs as escitalopram oxalate, a fine, white to slightly yellowish powder that is … Escitalopram
Physiological background Sweat is produced by millions of eccrine sweat glands that are distributed throughout the body and are particularly numerous on the palms and soles of the hands, face, and armpits. The eccrine sweat glands are spiral and clustered glands that open directly onto the skin surface. They are innervated by cholinergic nerve fibers … Heavy Sweating
Symptoms Rosacea is a chronic inflammatory skin disorder of the face that typically affects the cheeks, nose, chin, and central forehead symmetrically (Figure). The skin around the eyes is left out. It occurs more often in people with fair skin and in middle age, but it can occur in any skin type and at any … Rosacea Causes and Treatment
Products Acetylsalicylic acid is commercially available in the low dosage of 100 mg in the form of enteric-coated film-coated tablets (Aspirin Cardio, generics; in Germany and Austria, Aspirin Protect). The drug has been approved in many countries since 1992. Aspirin Cardio 300 mg is also used. In the United States, drugs with 81 mg (= … Acetylsalicylic Acid 100 mg
Products St. John’s wort and corresponding preparations are commercially available in the form of teas, film-coated tablets, dragées, capsules, and tinctures, among others (e.g., Jarsin, Rebalance, Remotiv, Ceres, Hyperiforce, Hyperiplant, Offenware). Stem plant Common St. John’s wort L. is a perennial plant of the St. John’s wort family, native to Europe and also common in … St. John’s Wort Health Benefits
