Structure and properties Polypeptide composed of 84 amino acids Synthesis and release Formation in the parathyroid glands Effects Bone resorption by activation of osteoclasts: increase in blood calcium levels Effect on kidney: Decrease in phosphate reabsorption: decrease in blood phosphate level. Decrease in calcium excretion: increase the level of calcium in the blood. Stimulation of … Parathyroid Hormone
Products Teriparatide is commercially available as a solution for injection in a prefilled injector (Forsteo, some countries also: Forteo). It was approved in the United States in 2002 and in the EU and many countries in 2003. The drug must be stored in a refrigerator and must not be frozen. Biosimilars are approved in many … Teriparatide
Products Biosimilars are copycat preparations of biotechnology-derived drugs (biologics) that have strong similarities to the originator drugs but that are not exactly the same. The similarity relates to biological activity, structure, function, purity and safety, among other things. Biosimilars differ from generics of small molecule drugs in important ways. Biosimilars are usually marketed as injection … Biosimilars
Symptoms In osteoporosis, bones become weak, porous, and brittle and undergo structural changes. Even minor stresses can lead to a fracture, especially of the vertebrae, femoral neck, and wrists. Fractures pose a risk to the elderly and can lead to pain, hospitalization, surgery and disability. In the worst cases, they are even life-threatening. Other possible … Osteoporosis Causes and Treatment