Definition A decrease in the number of platelets due to the administration of heparin is called heparin-induced thrombocytopenia (HIT). A distinction is made between two forms, the non-immunological form (HIT type I) and the antibody induced form (HIT type II). Introduction The word thrombocytopenia refers to a deficiency of thrombocytes, i.e. blood platelets. The word … Heparin-induced thrombocytopenia (HIT)
Causes Heparin-induced thrombocytopenia are either formed as a non-immunological, harmless early form (type I) or are based on the formation of antibodies against platelet factor 4/heparin complex (type II). These cause the blood to clump together and the platelets are, so to speak, “caught away” or “trapped”, they can no longer perform their natural function.Unfractionated … Causes | Heparin-induced thrombocytopenia (HIT)
Therapy The most important step in therapy is the immediate discontinuation of heparin if type II HIT is suspected. Also all other drugs containing heparin must not be used any further to prevent possible complications. These include ointments or catheter irrigations containing heparin. The anticoagulant therapy must be changed to non-heparin-based substances in order to … Therapy | Heparin-induced thrombocytopenia (HIT)
Introduction D-dimers are proteins that are formed when a thrombus is dissolved. They are cleavage products of fibrin that circulate freely in the blood. Their value is mainly determined when thrombosis is suspected. However, its significance is limited. A high D-dimer value can have many causes and does not clearly prove the presence of a … D-dimers
D-dimer test D-dimers are determined by means of a specific antibody test. This test is not only carried out to rule out thrombosis, but also for the diagnosis and monitoring of other diseases. In clinical routine the determination of D-dimers is performed indirectly by means of specific antibodies. These bind to a specific region of … D-dimer test | D-dimers
What symptoms does an increase in D-dimer cause? The symptoms caused by a D-dimer increase are essentially related to the underlying disease. The typical symptoms of a thromboembolic event include swelling of the affected body part, overheating, painful pressure, redness and a distinct feeling of tension. Pulmonary embolism is an acutely life-threatening situation that manifests … What symptoms does an increase in D-dimer cause? | D-dimers
Introduction Mono-Embolex® is a so-called anticoagulant, i.e. a drug that inhibits blood coagulation (anticoagulant) and is thus used primarily for the prophylaxis and therapy of venous thrombosis and pulmonary embolism. The active ingredient of the preparation Mono-Embolex® is certoparin sodium. The active ingredient Certoparin belongs to the class of low molecular weight (=fractionated) heparins. These … Mono-Embolex
Fields of application Low molecular weight heparins such as the active ingredient certoparin in Mono-Embolex® are suitable for thrombosis prophylaxis and thrombosis therapy. Thrombosis is a disease that occurs in the blood vessels. A blood clot is formed via the coagulation cascade, which closes the blood vessel. Often thromboses are localized in the veins and … Fields of application | Mono-Embolex
Therapy monitoring In contrast to a standard heparin, the fluctuations of the drug level in the body are significantly lower with low-molecular-weight heparin. For this reason, therapy monitoring is usually not absolutely necessary. Exceptions are patients who have an increased risk of bleeding and/or patients who suffer from renal insufficiency. In such cases, the determination … Therapy monitoring | Mono-Embolex
Pregnancy and lactation There is a lot of experience regarding the use of low molecular weight heparins in pregnancy. In the first 12 weeks of pregnancy, no harmful effect on the embryo could be observed when using Mono-Embolex®. This finding is based on approximately 2,800 observed pregnancies under Certoparin therapy. Mono-Embolex® does not appear to … Pregnancy and lactation | Mono-Embolex
Clexane® is the trade name of a drug with the active ingredient enoxaparin. This belongs to the group of low-molecular-weight heparins and is intended to inhibit blood coagulation by inhibiting the activity of a coagulation factor (factor Xa). Clexane® is used for the prophylaxis of thromboses, the treatment of thrombosis and pulmonary embolism and for … Clexane® during pregnancy
What are the side effects? The side effects of Clexane® correspond to the general side effects of the preparation. In addition there are a few special features that should be considered. If the risk-benefit ratio has been weighed well, the side effects are minor. A great advantage is that Clexane® does not cross the placental … What are the side effects? | Clexane® during pregnancy
