troglitazone

Thiazolidinediones (Glitazones)

Effects Glitazones are antidiabetic, antihyperglycemic, and antihyperglycemic, i.e., they decrease insulin resistance. Glitazones are selective and potent agonists at nuclear PPAR-γ. They improve glycemic control by enhancing insulin sensitivity in adipose tissue, skeletal muscle, and liver. Indications Type 2 diabetes mellitus Active ingredients Pioglitazone (Actos) Rosiglitazone (Avandia, off label). Troglitazone (Rezulin, out of commerce, liver … Thiazolidinediones (Glitazones)

Troglitazone

Products Troglitazone (Rezulin, tablets) is not commercially available in many countries. It was approved in 1997 and withdrawn from the market in 2000 because of its liver-toxic properties. Structure and properties Troglitazone (C24H27NO5S, Mr = 441.5 g/mol) belongs structurally to the thiazolidinediones. Effects Troglitazone (ATC A10BG01) is antidiabetic. Effects are due to agonism at the … Troglitazone