Products Rosiglitazone was commercially available in tablet form (Avandia). It had been approved since 1999 and was also commercially available in fixed combination with the biguanide metformin (Avandamet). The combination with the sulfonylurea glimepiride (Avaglim, EU, off-label) was not approved in many countries. A publication in on possible cardiovascular risks led to a controversy about … Rosiglitazone
Products Pioglitazone is commercially available in tablet form (Actos, generics). It is also available as a fixed-dose combination with metformin (Competact). Pioglitazone has been approved in many countries since 2000. Structure and properties Pioglitazone (C19H20N2O3S, Mr = 356.4 g/mol) belongs to the thiazolidinediones. It is present in drugs as a racemate and as pioglitazone hydrochloride, … Pioglitazone
Products Troglitazone (Rezulin, tablets) is not commercially available in many countries. It was approved in 1997 and withdrawn from the market in 2000 because of its liver-toxic properties. Structure and properties Troglitazone (C24H27NO5S, Mr = 441.5 g/mol) belongs structurally to the thiazolidinediones. Effects Troglitazone (ATC A10BG01) is antidiabetic. Effects are due to agonism at the … Troglitazone
