Effects
Glitazones are antidiabetic, antihyperglycemic, and antihyperglycemic, i.e., they decrease insulin resistance. Glitazones are selective and potent agonists at nuclear PPAR-γ. They improve glycemic control by enhancing insulin sensitivity in adipose tissue, skeletal muscle, and liver.
Indications
Type 2 diabetes mellitus
Active ingredients
- Pioglitazone (Actos)
- Rosiglitazone (Avandia, off label).
- Troglitazone (Rezulin, out of commerce, liver toxic) – 1. representative.
Glitazones are commercially available as monopreparations or in combination with sulfonylureas (glimepiride) and biguanides (metformin).
