Acute Scrotum: Drug Therapy Therapeutic target Caveat. Never accept a relevant loss of time. The guiding principle in the treatment of acute scrotum is: “Whenever doubt exists, it is safer to explore,” i.e., in case of doubt, surgical exposure of the testis Pain relief. Therapy recommendations Therapy for acute scrotum depends on the exact cause (see surgical therapy below). If necessary, symptomatic therapy with bed rest, cooling; if necessary, also antiphlogistics (anti-inflammatory)/analgesics(painkillers). If necessary, antibiosis (antibiotic therapy) for epididymitis (epididymitis). See also under “Further therapy”.