Products
Cetylpyridinium chloride is found in lozenges for sore throats (Angina MCC, Lidazone, Lysopain N, Mebucaine N, Neo-Angin, among others).
Structure and properties
Cetylpyridinium chloride or 1-hexadecylpyridinium cloride (C21H38ClN – H2O, Mr = 358.0 g/mol) is a quaternary ammonium base. It exists as a white powder that is soapy to the touch. The aqueous solution foams strongly when shaken.
Effects
Cetylpyridinium chloride (ATC D08AJ03) has antiseptic properties. It is a surface-active soap.
Indications
Cetylpyridinium chloride is used for local disinfection, mainly for inflammation of the mouth and throat, for halitosis, and usually in combination with other agents.
Contraindications
- Hypersensitivity
- Mucosal damage (delayed wound healing)
Full precautions can be found in the drug label.
Interactions
Effects are reduced by anionic soaps, such as those found in toothpaste. Quaternary ammonium compounds are inactivated by protein, serum, pus, phospholipids, and lipid-containing substances.
Adverse effects
Possible adverse effects include allergic reactions, sensitization, delay in wound healing, and discoloration of the tongue or teeth.