Conn Syndrome: Drug Therapy

Therapy goals

  • Normotension (normal blood pressure)
  • Normokalemia (normal level of potassium in the blood).

Therapy recommendations

Therapeutic depending on the diagnosis:

Diagnosis Pharmacotherapy Surgery
NNR (adrenal gland) adenoma and unilateral hyperplasia (unilateral excessive cell formation)
  • Aldosterone antagonists
 After blood pressure reduction and normalization of serum potassium levels, surgical removal of the tumor or affected adrenal gland.
Bilateral NNR hyperplasia.
  • Aldosterone antagonists
  • Amiloride (second-line agent).
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Glucocorticoid-suppressible primary hyperaldosteronism (excessive aldosterone secretion).