The following are the most important diseases or complications that may be contributed to by diabetic polyneuropathy:
Endocrine, nutritional, and metabolic diseases (E00-E90).
- Severe hypoglycemia (hypoglycemia) due to lack of awareness of symptoms.
- Diabetic foot or diabetic foot syndrome (DFS) – ulcerations (ulcers) on the feet due to circulatory disturbances of the limb and/or the decreased sensation of painNote: diabetic sensorimotor polyneuropathy (DSPN) is involved in 85-90% of the etiology (cause) of diabetic foot syndrome.
Infectious and parasitic diseases (A00-B99).
- Diabetic diarrhea (diarrhea).
- Infections of the skin ulcers (skin ulcers), which can lead to the need to amputate the affected limb due to poor wound healing
Skin and subcutaneous (L00-L99).
- Chronic ulceration (ulceration; typical localization: sole of foot and big toe; neuropathic ulcus pedis, the so-called malum perforans).
Cardiovascular system (I00-I99).
- Apoplexy (stroke)
- Myocardial infarction (heart attack)
- Orthostatic hypotension (low blood pressure).
Mouth, esophagus (food pipe), stomach, and intestines (K00-K67; K90-K93).
- Gastroparesis (loss of tone of gastric muscles) (due to autonomic neuropathy).
- Reflux disease (gastroesophageal reflux disease) (due toautonomic neuropathy).
Musculoskeletal system and connective tissue (M00-M99).
- Charcot foot (diabetic neuro-osteoarthropathy; disease of the foot in which bones break rapidly without the affected person feeling pain; 95% percent of all affected patients are diabetic).
- Osteomyelitis – bone inflammation due to deep skin and soft tissue infections.
Psyche – nervous system (F00-F99; G00-G99).
- Diabetic amyotrophy (usually unilateral (one-sided) upper lumbosacral plexopathy, LSP; pain syndrome).
- Diabetic radiculoplexopathy (synonyms: diabetic amyotrophy: see above; Bruns-Garland syndrome) – occurrence acute or subacute; associated with severe neuropathic pain; usually first occurs unilaterally and leads relatively quickly to muscle atrophy, mostly of the thigh muscles (because of autonomic neuropathy)
- Erectile dysfunction (ED; erectile dysfunction) (due toautonomic neuropathy).
- Cranial nerve palsies (cranial nerve paralysis):
- III oculomotor nerve (eye movement nerve); type: motor; function: eye and eyelid movement; adaptation to distance.
- IV trochlear nerve; type: motor; function: superior oblique eye muscle.
- VII facial nerve (facial nerve); type: sensory/motor; function: sensory: anterior part of tongue motor: facial mimic muscles
- Mononeuritis multiplex – inflammation of individual nerves in different parts of the body.
- Mononeuropathies (damage to a single peripheral nerve) – increased risk of nerve compression syndromes, such as sulcus ulnaris or carpal tunnel syndrome
Genitourinary system (kidneys, urinary tract – reproductive organs) (N00-N99).
- Bladder atony (flaccidity of bladder muscles) (due to autonomic neuropathy).
- Ejaculatory dysfunction (due toautonomic neuropathy).
- Decreased vaginal lubrication (moisture of the vagina) (due toautonomic neuropathy).
Symptoms and abnormal clinical and laboratory findings not classified elsewhere (R00-R99).
- Diarrhea (diabetic diarrhea/diarrhea) (due to autonomic neuropathy).
- Constipation (constipation) (due toautonomic neuropathy).
- Tachycardia (heartbeat too fast: > 100 beats per minute; here: resting tachycardia) (due toautonomic neuropathy).
Further
