Products
The marketing of medicinal products containing dihydroergotamine has been discontinued in many countries (e.g., Dihydergot tablets and nasal spray, Ergotonin, Effortil plus, Old Tonopan, and others). The approval of Dihydergot tablets was cancelled on February 1, 2014, because the benefits no longer outweighed the potential risks, according to drug regulators.
Structure and properties
Dihydroergotamine (C33H37N5O5, 583.7 g/mol) is present in drugs as dihydroergotamine mesilate, a white crystalline powder or colorless crystals that are sparingly soluble in water.
Indications
Earlier indications:
- For the treatment of acute migraine attacks with or without aura.
- Low blood pressure
- Migraine prevention
