Estradiol is a natural estrogen. It is synthesized in the ovaries (ovaries) and connective tissue.
Estrone (E1) has only one-third of the biological potency of estradiol.Like all sex hormones, it is made from cholesterol. Estrone is secreted directly by hormone-producing cells (e.g., in the ovaries or adrenal gland) before menopause. After menopause, estrone is produced indirectly by conversion of the hormone androstenedione. This conversion takes place mainly in adipose tissue, muscle and liver. Estrone is thus the most important estrogen in postmenopause (time after menopause) – it is considered the lead hormone of postmenopause.
The procedure
Material needed
- Blood serum
Preparation of the patient
- No preparation necessary
Disruptive factors
- None known
Normal values for women
| Age | Normal values in pg/ml |
| Sexual maturity | > 50 |
| Postmenopausal | < 40 |
Indications
- Cycle disorders in obesity
- Estrogen status in postmenopause
- Determination of estrogen action in postmenopause.
- Unclear bleeding in the postmenopause
- Therapy monitoring under estrone therapy.
Interpretation
Interpretation of increased values
- Obesity (obesity) – estrone is formed in adipose tissue by conversion of the hormone androstenedione