Products
Mebendazole is commercially available in the form of tablets (Vermox). It has been approved in many countries since 1974.
Structure and properties
Mebendazole (C15H13N3O3, Mr = 295.3 g/mol) is a benzimidazole derivative and a carbamate. It exists as a white powder that is practically insoluble in water.
Effects
Mebendazole (ATC P02CA01) has antihelminthic properties. The effects are due to binding to tubulin and disruption of microtubules, thereby inhibiting cell division. Due to a high first-pass metabolism, it is predominantly effective locally in the intestine.
Indications
For the treatment of intestinal worm infections with nematodes (often pinworms) and certain tapeworms. High-dose tablets are available for the treatment of echinococcosis.
Dosage
According to the product label. Treatment depends on the causative worm. To treat an infestation of pinworms, one tablet is administered as a single dose with a meal. The dose is repeated after two weeks (note: the German technical information recommends a treatment duration of three days).
Contraindications
- Hypersensitivity
- Combination with metronidazole
- Infants < 1 year, only with caution in infants < 2 years.
- Pregnancy
Full precautions can be found in the drug label.
Interactions
Drug-drug interactions have been described with cimetidine, enzyme inducers (carbamazepine, phenytoin), insulins, and metronidazole.
Adverse effects
The most common possible adverse effects include digestive disturbances such as abdominal pain, diarrhea, and flatulence. Severe adverse reactions may occur very rarely.
