Products
Flufenamic acid is commercially available as cream, gel, emgel, and ointment exclusively in combination preparations for external use (e.g., Assan). It was developed in the 1960s.
Structure and properties
Flufenamic acid (C14H10F3NO2, Mr = 281.23 g/mol) belongs to the anthranilic acid derivatives and fenamates, like etofenamate and mefenamic acid.
Effects
Flufenamic acid (ATC M01AG03) has analgesic and anti-inflammatory properties. The effects are due to inhibition of prostaglandin synthesis by inhibition of the enzyme cyclooxygenase (COX). Furthermore, flufenamic acid interacts with various ion channels and is therefore used in pharmacological research.
Indications
- Rheumatic complaints.
- Painful, inflammatory and degenerative diseases of the musculoskeletal system, muscles, tendons, ligaments and joints, as well as the spine or intervertebral discs.
- Blunt injuries such as bruises, sprains, strains.
Dosage
According to the package leaflet. The drugs are applied locally two to three times a day.
Contraindications
- Hypersensitivity, including to other NSAIDs
- Open, injured or diseased skin
- Children, pregnancy, lactation
- Renal failure
Full precautions can be found in the drug label.
Interactions
Interactions with other drugs are not known to date.
Adverse effects
Possible adverse effects include local skin reactions.