Gliomas: Prevention

To prevent gliomas, attention must be paid to reducing individual risk factors.

Behavioral risk factors

  • Psychosocial situation
    • High earnings – in men, risk increase for glioma by 14%.

Environmental pollution – intoxications (poisoning).

  • Carcinogens
  • Ionizing rays

Further

  • After head and neck CT, the risk of tumors is increased for children. This is especially true for thyroid carcinomas (increased by 78%) and brain tumors (increased by 60%). The overall cancer incidence is increased by 13%.
  • Cell phone use (cell phones; fixed wireless devices) – statistically significant risk of glioma with cell phone use > 1 year; esp. high risk was associated with exposure before age 20.

Prevention factors (protective factors)

  • Genetic factors:
    • Genetic risk reduction dependent on gene polymorphisms, related to gliomas:
      • Genes/SNPs (single nucleotide polymorphism):
        • Gene: PARP1
        • SNP: rs1136410 in gene PARP1
          • Allele constellation: CT (0.80-fold).
          • Allele constellation: CC (<0.80-fold)