Plasmacytoma

Plasmocytoma: Or something else? Differential Diagnosis

Musculoskeletal system and connective tissue (M00-M99). Osteoporosis (bone loss) Rheumatism or rheumatic diseases Neoplasms – tumor diseases (C00-D48) Monoclonal gammopathy – paraproteinemia with appearance of monoclonal antibodies. Waldenström’s disease (synonym: Waldenström’s macroglobulinemia) – malignant (malignant) lymphoma disease; is counted among the B-cell non-Hodgkin’s lymphomas; typical is an abnormal production of monoclonal immunoglobulin M (IgM) by … Plasmocytoma: Or something else? Differential Diagnosis

Plasmacytoma: Complications

The following are the most important diseases or complications that may be contributed to by a plasmacytoma: Blood, blood-forming organs – Immune system (D50-D90). Antibody deficiency syndrome with increased tendency to infection. Hemorrhagic diathesis – blood clotting disorder with increased bleeding tendency. Pancytopenia (synonym: tricytopenia) – reduction of all three cell series in the blood. … Plasmacytoma: Complications

Plasmocytoma: Classification

Symptomatic multiple myeloma (plasmocytoma) is defined by the revised IMWG criteria as follows: Presence of monoclonal plasma cells in bone marrow ≥ 10% or biopsy-confirmed plasmacytoma of bone or extramedullary manifestation and any of the following “myeloma-defining events.” CRAB criteria for the diagnosis of multiple myeloma (see below Laboratory Diagnostics). Hypercalcemia (calcium excess) C (hypercalcaemia) … Plasmocytoma: Classification

Plasmocytoma: Examination

A comprehensive clinical examination is the basis for selecting further diagnostic steps: General physical examination – including blood pressure, pulse, body temperature, body weight, body height; furthermore: Inspection (viewing). Skin, mucous membranes and sclerae (white part of the eye) [leading symptom: night sweats]. Abdomen (abdomen) Shape of the abdomen? Skin color? Skin texture? Efflorescences (skin … Plasmocytoma: Examination

Plasmocytoma: Test and Diagnosis

1st order laboratory parameters – obligatory laboratory tests. Small blood count [normochromic anemia, leukopenia, and thrombocytopenia] Differential blood count Inflammatory parameters – CRP (C-reactive protein) or ESR (erythrocyte sedimentation rate) [↑↑↑] Calcium [↑] Urine status (rapid test for: pH, leukocytes, nitrite, protein, blood), sediment, if necessary urine culture (pathogen detection and resistogram, that is, testing … Plasmocytoma: Test and Diagnosis

Plasmocytoma: Drug Therapy

Therapeutic target Achievement of remission (remission of disease symptoms). Therapy recommendations SLiM-CRAB criteria of multiple myeloma requiring therapy. Therapy requirement formally occurs when any of the following SLiM-CRAB criteria are met: Myeloma-defining biomarkers (SLiM criteria). Clonal plasma cell infiltration in the bone marrow ≥ 60 % (English ” sixty percent”) Ratio of free light chains … Plasmocytoma: Drug Therapy

Plasmocytoma: Medical History

Medical history (history of illness) represents an important component in the diagnosis of plasmacytoma. Family history Is there a history of frequent tumors in your family? Social history What is your profession? Are you exposed to harmful working substances in your profession? Mineral oil? Current medical history/systemic medical history (somatic and psychological complaints). What complaints … Plasmocytoma: Medical History

Plasmocytoma: Diagnostic Tests

Mandatory medical device diagnostics. Radiograph of the skull, thorax (radiograph thorax in two planes), pelvis, skeleton (here: humeri/upper arm bones and femora/thigh bones), and if necessary of the sternum (sternum) and ribs; spine in 3 sections, each in 2 planes – to exclude osteolysis (spatially circumscribed dissolution or degeneration of bone tissue) [skull image shows … Plasmocytoma: Diagnostic Tests

Plasmacytoma: Prevention

To prevent plasmacytoma, attention must be paid to reducing individual risk factors. Behavioral risk factors Diet Micronutrient deficiency (vital substances) – see Prevention with micronutrients. Overweight (BMI ≥ 25; obesity). Environmental pollution – intoxications (poisoning). Ionizing radiation The following groups of people are frequently affected: Workers in wood processing Workers in the leather industry Farmers … Plasmacytoma: Prevention

Plasmocytoma: Radiotherapy

Plasmocytoma (multiple myeloma, MM) is highly radiosensitive. During the course of the disease, approximately 40% of all patients require radiotherapy (RT), mainly with the palliative goals of pain relief and fracture prevention. Radiotherapeutic measures for plasmacytoma: Special case: solitary plasmacytoma: single involvement in bone (“solitary bone plasmacytoma”, SBP) or extramedullary involvement (“solitary extramedullary plasmacytoma”, SEP) … Plasmocytoma: Radiotherapy

Plasmacytoma: Symptoms, Complaints, Signs

The following symptoms and complaints may indicate plasmacytoma: Leading symptoms Bone pain* (diffuse) and musculoskeletal pain, especially in the back; increasing with movement (bone pain results from osteolysis (bone loss) or osteoporosis (bone loss) of the spine and ribs; note: in vertebrae, the vertebral bodies themselves are particularly affected; in contrast, in carcinoma metastases, the … Plasmacytoma: Symptoms, Complaints, Signs

Plasmocytoma: Therapy Options

Plasmocytoma is not curable. The goal of therapy is remission (temporary lessening of the signs of the disease). Therapy is based on the stage: Stage I – “wait and see” (regular examinations). Stage II/III – usually combined radiotherapy and chemotherapy. In individuals <70 years of age, autologous stem cell transplantation (blood stem cell transplantation).