Therapy target Improvement of the symptomatology Therapy recommendations Psychotherapy or psychopharmacotherapy or a combination of both. Psychopharmacotherapy First-line agents: citalopram, escitalopram, paroxetine, sertraline (selective serotonin reuptake inhibitors, SSRIs); duloxetine, venlafaxine (selective serotonin-norepinephrine reuptake inhibitors, SSNRIs). Second-line agents: clomipramine, imipramine (tricyclic antidepressants); buspirone (benzodiazepine-like substances), hydroxyzine (anxiolytics/drugs that have an antianxiety effect), pregabalin (new antiepileptic drugs). … Anxiety Disorders: Drug Therapy