Products Nabilone is commercially available in the United States, the United Kingdom, and Germany, for example, in the form of capsules (Cesamet, Canemes). It is a narcotic drug. In many countries, the drug is not registered. The active ingredient was developed in the 1970s. Structure and properties Nabilone (C24H36O3, Mr = 372.5 g/mol) is a … Nabilon
Products The fixed combination of netupitant and palonosetron has been approved in capsule form (Akynzeo). The drug was released in many countries in 2015. Structure and properties Netupitant (C30H32F6N4O, Mr = 578.6 g/mol) is a fluorinated piperazine and pyrimidine derivative. Palonosetron (C19H24N2O, Mr = 296.4 g/mol) is present in drugs as palonosetron hydrochloride, a white … Netupitant, Palonosetron
Products Ondansetron is commercially available in the form of film-coated tablets, meltable tablets (lingual tablets), as a syrup, and as an infusion/injection preparation. In addition to the original Zofran, generic versions are also available. Ondansetron was introduced in 1991 as the first active ingredient from the group of 5-HT3 receptor antagonists was approved. Structure and … Ondansetron
Products Granisetron is commercially available as film-coated tablets and as an infusion concentrate (Kytril, generic). It has been approved in many countries since 1991. A transdermal patch was approved in the EU in 2012 (Sancuso). Structure and properties Granisetron (C18H24N4O, Mr = 312.4 g/mol) is an indazole derivative. It is present in drugs as granisetron … Granisetron
Products Dolasetron (Anzemet) is no longer on the market in many countries. It had been approved since 1999. The solution for injection was withdrawn in 2011 because of possible adverse effects (prolongation of the QT interval, cardiac arrhythmias), and later the tablets also went off the market. Structure and properties Dolasetron (C19H20N2O3, Mr = 324.4 … Dolasetron
Products Aprepitant is commercially available in the form of capsules (Emend). It has been approved in many countries since 2003. Structure and properties Aprepitant (C23H21F7N4O3, Mr = 534.4 g/mol) is a morpholine and triazol-3-one derivative. It exists as a white crystalline powder that is practically insoluble in water. For intravenous use, the more water-soluble prodrug … Aprepitant
Products Palonosetron is commercially available as a solution for injection and as soft capsules (Aloxi, generic). It has been approved in many countries since 2006. The capsules were registered in 2013. Also approved is a fixed combination of netupitant and palonosetron in capsule form; see netupitant palonosetron. Structure and properties Palonosetron (C19H24N2O, Mr = 296.4 … Palonosetron
Products Serotonin receptor antagonists are commercially available in the form of film-coated tablets, melting tablets, soft capsules, as syrups, and as infusion/injection preparations. This article refers to the setrone (5-HT3 receptor antagonists), which are used as antiemetics. The first agent from this group to be approved in the United States was ondansetron (Zofran) in 1991, … Serotonin Antagonists (Setrone)
Products Tropisetron was approved in many countries starting in 1992 as a solution for injection and in capsule form (Navoban). It was withdrawn from the market in 2013. Structure and properties Tropisetron (C17H20N2O2, Mr = 284.4 g/mol) is an indole and tropane derivative. It exists as a white powder that is soluble in water. Effects … Tropisetron
Products Rolapitant was approved in the form of film-coated tablets in the United States in 2015, in the EU in 2017, and in many countries in 2018 (Varuby). Structure and properties Rolapitant (C25H26F6N2O2, Mr = 500.5 g/mol) is present in the drug as rolapitane hydrochloride, a white powder that is more soluble in water at … Rolapitant
Products Fosaprepitant is commercially available as an infusion preparation (Ivemend). It has been approved in many countries since 2008. Structure and properties Fosaprepitant (C23H22F7N4O6P, Mr = 614.4 g/mol) is the prodrug of aprepitant (Emend). Unlike aprepitant, which is administered orally, fosaprepitant is administered parenterally and is more water soluble. Detailed information See under aprepitant
