Products Ondansetron is commercially available in the form of film-coated tablets, meltable tablets (lingual tablets), as a syrup, and as an infusion/injection preparation. In addition to the original Zofran, generic versions are also available. Ondansetron was introduced in 1991 as the first active ingredient from the group of 5-HT3 receptor antagonists was approved. Structure and … Ondansetron
Products Granisetron is commercially available as film-coated tablets and as an infusion concentrate (Kytril, generic). It has been approved in many countries since 1991. A transdermal patch was approved in the EU in 2012 (Sancuso). Structure and properties Granisetron (C18H24N4O, Mr = 312.4 g/mol) is an indazole derivative. It is present in drugs as granisetron … Granisetron
Products Dolasetron (Anzemet) is no longer on the market in many countries. It had been approved since 1999. The solution for injection was withdrawn in 2011 because of possible adverse effects (prolongation of the QT interval, cardiac arrhythmias), and later the tablets also went off the market. Structure and properties Dolasetron (C19H20N2O3, Mr = 324.4 … Dolasetron
Products Palonosetron is commercially available as a solution for injection and as soft capsules (Aloxi, generic). It has been approved in many countries since 2006. The capsules were registered in 2013. Also approved is a fixed combination of netupitant and palonosetron in capsule form; see netupitant palonosetron. Structure and properties Palonosetron (C19H24N2O, Mr = 296.4 … Palonosetron
Products Tropisetron was approved in many countries starting in 1992 as a solution for injection and in capsule form (Navoban). It was withdrawn from the market in 2013. Structure and properties Tropisetron (C17H20N2O2, Mr = 284.4 g/mol) is an indole and tropane derivative. It exists as a white powder that is soluble in water. Effects … Tropisetron
