Products Prasugrel is commercially available in the form of film-coated tablets (Efient). It was approved in many countries, in the EU and in the US in 2009. Generic versions were registered in 2019. Structure and properties Prasugrel (C20H20FNO3S, Mr = 373.4 g/mol) belongs to the group of thienopyridines and exists as a hydrochloride as a … Prasugrel
Products Clopidogrel is commercially available in tablet form (Plavix, generics). It has been approved in the United States since 1997 and in many countries and the EU since 1998. Clopidogrel is also combined with acetylsalicylic acid fixed (DuoPlavin). Structure and properties Clopidogrel (C16H16ClNO2S, Mr = 321.82 g/mol) is a thienopyridine derivative and a prodrug. It … Clopidogrel: Drug Effects, Side Effects, Dosage and Uses
Products Cangrelor is commercially available as a powder for the preparation of an infusion solution (Kengrexal). It was approved in many countries in 2015. Structure and properties Cangrelor (C17H25Cl2F3N5O12P3S2, Mr = 776.4 g/mol) is an analog of adenosine triphosphate. Unlike other P2Y12 antagonists, it is not a prodrug. It is present in the drug as … Cangrelor
Products Ticagrelor is commercially available in the form of film-coated tablets (Brilique). The active ingredient was approved in many countries in 2011. In 2018, additional meltable tablets were registered. Structure and properties Ticagrelor (C23H28F2N6O4S, Mr = 522.6 g/mol) is a cyclopentyltriazolopyrimidine without a thienopyridine structure. Ticagrelor is directly active. It has an active metabolite but, … Ticagrelor
Products Ticlopidine is out of commerce in many countries because of its adverse effects (thrombocytopenic purpura, blood count disorders). Ticlid film-coated tablets are no longer available. Structure and properties Ticlopidine (C14H14ClNS, Mr = 263.8 g/mol) is a thienopyridine that is structurally closely related to clopidogrel. Effects Ticlopidine (ATC B01AC05) is antiplatelet; see under P2Y12 antagonists. … Ticlopidine
Products The fixed combination containing 81 mg acetylsalicylic acid and 20 mg esomeprazole was approved in many countries in June 2012 in capsule form (Axanum). In the EU, the drug has been registered since 2011. The amount of acetylsalicylic acid contained is less than in Aspirin cardio and generics, which usually contain 100 mg of … Acetylsalicylic Acid and Esomeprazole